Inhibition of vascular adhesion protein-1 modifies hepatic steatosis in vitro and in vivo

April 9, 2021
Non-alcoholic fatty liver illness (NAFLD) is related to weight problems, insulin resistance and dyslipidaemia and at present is estimated to have an effect on as much as a 3rd of all people in developed nations. Current commonplace of look after sufferers varies in accordance with illness stage, however consists of way of life interventions frequent insulin sensitizers, antioxidants and lipid modifiers. However, so far particular therapies have proven little histological or fibrosis stage enchancment in giant scientific trials, and there may be nonetheless no licensed remedy for NAFLD. Given the excessive prevalence, restricted remedy choices and important screening prices for the general inhabitants, new therapies are urgently required.
 To assess the potential for inhibition of the amine oxidase enzyme vascular adhesion protein-1 (VAP-1) to change hepatic lipid accumulation in NAFLD. We have used immunochemical and qPCR evaluation to doc expression of VAP-1 and key practical proteins and transporters throughout the NAFLD spectrum. We then utilised hepatocytes in tradition and human precision reduce liver slices in live performance with selective enzyme exercise inhibitors to check the consequences of activating the semicarbazide-sensitive amine oxidase exercise of VAP-1 on hepatic lipid uptake and triglyceride export.
We confirmed that growing severity of NAFLD and development to cirrhosis was related to a big enhance in hepatocellular VAP-1 expression. Hepatocytes in vitro uncovered to recombinant VAP-1 and its substrate methylamine confirmed elevated lipid accumulation as decided by quantification of Oil Red O uptake. This was recapitulated utilizing hydrogen peroxide, and lipid accumulation was accompanied by adjustments in expression of the lipid transporter molecules FABP3, FATP6, insulin receptor subunits and PPARα.
Human liver tissue uncovered to recombinant VAP-1 or substrates for endo/exogenous VAP-1 produced much less triglyceride than untreated tissue and demonstrated a rise in steatosis. This response may very well be inhibited through the use of bromoethylamine to inhibit the SSAO exercise of VAP-1, and mice poor in VAP-1/AOC3 additionally demonstrated diminished steatosis on excessive fats weight loss plan. Exposure of human liver tissue to methylamine to activate VAP-1 resulted in elevated expression of FABP2 and 4, FATP3-5, caveolin-1, VLDLR, PPARGC1 and genes related to the inflammatory response.
 Our information verify that the elevations in hepatic VAP-1 expression reported in nonalcoholic steatohepatitis can contribute to steatosis, metabolic disturbance and irritation. This means that concentrating on the semicarbazide delicate amine oxidase capability of VAP-1 could symbolize a helpful adjunct to different therapeutic methods in NAFLD. A murine mannequin of NAFLD was additionally used to find out the results of VAP-1 knockout and gene expression arrays had been used to quantify the consequences of VAP-1 exercise on key lipid modifying and proinflammatory gene expression.

Autophagy alleviates hypoxia-induced blood-brain barrier damage through regulation of CLDN5 (claudin 5)

 

Blood-brain barrier (BBB) disruption is a key occasion in triggering secondary harm to the central nervous system (CNS) underneath stroke, and is often related to irregular macroautophagy/autophagy in mind microvascular endothelial cells (BMECs). However, the underlying mechanism of autophagy in sustaining BBB integrity stays unclear. Here we report that in BMECs of sufferers struggling stroke, CLDN5 (claudin 5) abnormally aggregates in the cytosol accompanied by autophagy activation. In vivo zebrafish and in vitro cell research reveal that BBB breakdown is partially attributable to CAV1 (caveolin 1)-mediated redistribution of membranous CLDN5 into the cytosol underneath hypoxia.

Meanwhile, autophagy is activated and contributes primarily to the degradation of CAV1 and aggregated CLDN5 in the cytosol of BMECs, due to this fact assuaging BBB breakdown. Blockage of autophagy by genetic strategies or chemical compounds aggravates cytosolic aggregation of CLDN5, ensuing in severer BBB impairment. These information display that autophagy capabilities in the safety of BBB integrity by regulating CLDN5 redistribution and present a possible therapeutic technique for BBB disorder-related cerebrovascular illness.

BBB: blood-brain barrier; BECN1: beclin 1; BMEC: mind microvascular endothelial cell; CAV1: caveolin 1; CCA: frequent carotid artery; CLDN5: claudin 5; CNS: central nervous system; CQ: chloroquine; HIF1A: hypoxia inducible issue 1 subunit alpha; MCAO: center cerebral artery occlusion-reperfusion; OCLN: occludin; ROS: reactive oxygen species; STED: stimulated emission depletion; TEER: trans-endothelial electrical resistance; TEM: transmission electron microscopy; TJ: tight junction; TJP1: tight junction protein 1; UPS: ubiquitin-proteasome system.

Inhibition of vascular adhesion protein-1 modifies hepatic steatosis in vitro and in vivo

Transcriptomic evaluation of tobacco-flavored E-cigarette and menthol-flavored E-cigarette publicity in the human center ear

Electronic cigarettes (e-cigarettes) are essentially the most broadly used digital nicotine supply techniques and are designed to mimic smoking and help in smoking cessation. Although the quantity of e-cigarette customers is growing quickly, particularly amongst younger adults and adolescents, the potential well being impacts and biologic results of e-cigarettes nonetheless have to be elucidated. Our earlier research demonstrated the cytotoxic results of digital liquids (e-liquids) in a human center ear epithelial cell (HMEEC-1) line, which had been affected by the producer and flavoring brokers regardless of the presence of nicotine.

In this research, we aimed to judge the gene expression profile and determine potential molecular modulator genes and pathways in HMEEC-1 uncovered to 2 completely different e-liquids (tobacco- and menthol-flavored). HMEEC-1 was uncovered to e-liquids, and RNA sequencing, practical evaluation, and pathway evaluation had been performed to determine the resultant transcriptomic adjustments. A complete of 843 genes had been differentially expressed following publicity to the tobacco-flavored e-liquid, amongst which 262 genes had been upregulated and 581 had been downregulated.

Upon publicity to the menthol-flavored e-liquid, a complete of 589 genes had been differentially expressed, amongst which 228 genes had been upregulated and 361 had been downregulated. Among the signaling pathways related to the differentially expressed genes mediated by tobacco-flavored e-liquid publicity, a number of key molecular genes had been recognized, together with IL6 (interleukin 6), PTGS2 (prostaglandin-endoperoxide synthase 2), CXCL8 (C-X-C motif chemokine ligand 8), JUN (Jun proto-oncogene), FOS (Fos proto-oncogene), and TP53 (tumor protein 53).

Caveolin-1 (CAV1) Rabbit anti-Human Polyclonal Antibody
GWB-106B42 0.05 mg Ask for price

Caveolin-1 (CAV1) Rabbit anti-Human Polyclonal Antibody
GWB-F5D255 0.05 mg Ask for price

Caveolin-1 (CAV1) Rabbit anti-Human Polyclonal Antibody
GWB-FF1B2C 0.05 mg Ask for price

Rabbit Anti Human Caveolin 1 (N-Terminal) Polyclonal Antibody
CPBT-65030RH 50 µg
EUR 1182

Rabbit polyclonal Caveolin-1 antibody
TA326097 100 µl Ask for price

Rabbit Polyclonal Caveolin-1 Antibody
TA325301 100 µl Ask for price

Caveolin 2 Rabbit Polyclonal Antibody
E10G22750 100 μl
EUR 275
Description: Biotin-Conjugated, FITC-Conjugated , AF350 Conjugated , AF405M-Conjugated ,AF488-Conjugated, AF514-Conjugated ,AF532-Conjugated, AF555-Conjugated ,AF568-Conjugated , HRP-Conjugated, AF405S-Conjugated, AF405L-Conjugated , AF546-Conjugated, AF594-Conjugated , AF610-Conjugated, AF635-Conjugated , AF647-Conjugated , AF680-Conjugated , AF700-Conjugated , AF750-Conjugated , AF790-Conjugated , APC-Conjugated , PE-Conjugated , Cy3-Conjugated , Cy5-Conjugated , Cy5.5-Conjugated , Cy7-Conjugated Antibody

Caveolin-1 (phospho Tyr14) Rabbit Polyclonal Antibody
ES1279-100ul 100ul
EUR 124
Description: A Rabbit Polyclonal antibody against Caveolin-1 (phospho Tyr14) from Human/Mouse/Rat. This antibody is tested and validated for WB, ELISA, WB, ELISA

Caveolin-1 (phospho Tyr14) Rabbit Polyclonal Antibody
ES1279-50ul 50ul
EUR 74
Description: A Rabbit Polyclonal antibody against Caveolin-1 (phospho Tyr14) from Human/Mouse/Rat. This antibody is tested and validated for WB, ELISA, WB, ELISA

Caveolin-3 (CAV3) Rabbit anti-Human Polyclonal (aa19-41) Antibody
GWB-DA1453 0.05 ml Ask for price

Polyclonal Antibody to Caveolin 1 (CAV1)
PAA214Hu01 100ul
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Polyclonal Antibody to Caveolin 1 (CAV1)
PAA214Hu08 100ul
EUR 242

Polyclonal Antibody to Caveolin 1 (CAV1)
PAA214Mu01 100ul
EUR 227

Polyclonal Antibody to Caveolin 1 (CAV1)
PAA214Ra01 100ul
EUR 239

Caveolin 1 (CAV1) rabbit polyclonal antibody, Aff - Purified
AP02643PU-N 100 µg Ask for price

Caveolin 1 (CAV1) rabbit polyclonal antibody, Aff - Purified
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Caveolin 1 (CAV1) rabbit polyclonal antibody, Aff - Purified
AP06040PU-N 100 µg Ask for price

Caveolin 1 (CAV1) rabbit polyclonal antibody, Aff - Purified
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Caveolin-2 (phospho Tyr27) Rabbit Polyclonal Antibody
ES7828-100ul 100ul
EUR 124
Description: A Rabbit Polyclonal antibody against Caveolin-2 (phospho Tyr27) from Human. This antibody is tested and validated for WB, ELISA, WB, ELISA

Caveolin-2 (phospho Tyr27) Rabbit Polyclonal Antibody
ES7828-50ul 50ul
EUR 74
Description: A Rabbit Polyclonal antibody against Caveolin-2 (phospho Tyr27) from Human. This antibody is tested and validated for WB, ELISA, WB, ELISA

Caveolin 3 (CAV3) (N-term) rabbit polyclonal antibody
AP17187PU-N 400 µl Ask for price

Caveolin 1 (CAV1) (C-term) rabbit polyclonal antibody, Purified
AP31042PU-N 250 µl Ask for price

Caveolin 3 (CAV3) (19-41) rabbit polyclonal antibody, Serum
AP08227PU-N 100 µl Ask for price

Rabbit Polyclonal Caveolin-1 (Tyr14) Antibody (Phospho-specific)
TA325302 100 µl Ask for price

Caveolin 1 (CAV1) pTyr14 rabbit polyclonal antibody, Aff - Purified
AP02388PU-N 100 µg Ask for price

Caveolin 1 (CAV1) pTyr14 rabbit polyclonal antibody, Aff - Purified
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Caveolin 1 (CAV1) pTyr14 rabbit polyclonal antibody, Aff - Purified
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Caveolin-1 Polyclonal Antibody
40684-100ul 100ul
EUR 302.4

Caveolin-1 Polyclonal Antibody
40684-50ul 50ul
EUR 224.4

Caveolin-1 Polyclonal Antibody
E040684 100μg/100μl
EUR 255
Description: Available in various conjugation types.

Caveolin-1 Polyclonal Antibody
E20-70685 100ug
EUR 225
Description: Available in various conjugation types.

Caveolin-1 Polyclonal Antibody
E20-70686 100ug
EUR 225
Description: Available in various conjugation types.

Caveolin-1 Polyclonal Antibody
ABP50873-003ml 0.03ml
EUR 189.6
Description: A polyclonal antibody for detection of Caveolin-1 from Human, Mouse, Rat. This Caveolin-1 antibody is for WB, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from human Caveolin-1 around the non-phosphorylation site of Y14

Caveolin-1 Polyclonal Antibody
ABP50873-01ml 0.1ml
EUR 346.8
Description: A polyclonal antibody for detection of Caveolin-1 from Human, Mouse, Rat. This Caveolin-1 antibody is for WB, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from human Caveolin-1 around the non-phosphorylation site of Y14

Caveolin-1 Polyclonal Antibody
ABP50873-02ml 0.2ml
EUR 496.8
Description: A polyclonal antibody for detection of Caveolin-1 from Human, Mouse, Rat. This Caveolin-1 antibody is for WB, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from human Caveolin-1 around the non-phosphorylation site of Y14

Caveolin-1 Polyclonal Antibody
ABP50874-003ml 0.03ml
EUR 189.6
Description: A polyclonal antibody for detection of Caveolin-1 from Human, Mouse, Rat. This Caveolin-1 antibody is for WB, IHC-P, IF, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from the C-terminal region of human Caveolin-1 at AA range: 100-180

Caveolin-1 Polyclonal Antibody
ABP50874-01ml 0.1ml
EUR 346.8
Description: A polyclonal antibody for detection of Caveolin-1 from Human, Mouse, Rat. This Caveolin-1 antibody is for WB, IHC-P, IF, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from the C-terminal region of human Caveolin-1 at AA range: 100-180

Caveolin-1 Polyclonal Antibody
ABP50874-02ml 0.2ml
EUR 496.8
Description: A polyclonal antibody for detection of Caveolin-1 from Human, Mouse, Rat. This Caveolin-1 antibody is for WB, IHC-P, IF, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from the C-terminal region of human Caveolin-1 at AA range: 100-180

Caveolin-1 Polyclonal Antibody
E44H01735 100ul
EUR 255
Description: Biotin-Conjugated, FITC-Conjugated , AF350 Conjugated , AF405M-Conjugated ,AF488-Conjugated, AF514-Conjugated ,AF532-Conjugated, AF555-Conjugated ,AF568-Conjugated , HRP-Conjugated, AF405S-Conjugated, AF405L-Conjugated , AF546-Conjugated, AF594-Conjugated , AF610-Conjugated, AF635-Conjugated , AF647-Conjugated , AF680-Conjugated , AF700-Conjugated , AF750-Conjugated , AF790-Conjugated , APC-Conjugated , PE-Conjugated , Cy3-Conjugated , Cy5-Conjugated , Cy5.5-Conjugated , Cy7-Conjugated Antibody

Caveolin-1 Polyclonal Antibody
E44H01736 100ul
EUR 255
Description: Biotin-Conjugated, FITC-Conjugated , AF350 Conjugated , AF405M-Conjugated ,AF488-Conjugated, AF514-Conjugated ,AF532-Conjugated, AF555-Conjugated ,AF568-Conjugated , HRP-Conjugated, AF405S-Conjugated, AF405L-Conjugated , AF546-Conjugated, AF594-Conjugated , AF610-Conjugated, AF635-Conjugated , AF647-Conjugated , AF680-Conjugated , AF700-Conjugated , AF750-Conjugated , AF790-Conjugated , APC-Conjugated , PE-Conjugated , Cy3-Conjugated , Cy5-Conjugated , Cy5.5-Conjugated , Cy7-Conjugated Antibody

Goat Anti Caveolin 1 Polyclonal Antibody
CPBT-65031GC 0.1 mg
EUR 1033.2

Polyclonal Caveolin-1 Antibody
APG02445G 0.05ml
EUR 633.6
Description: A polyclonal antibody raised in Rabbit that recognizes and binds to Human Caveolin-1 . This antibody is tested and proven to work in the following applications:

Polyclonal Caveolin-1 Antibody
APG02446G 0.1ml
EUR 580.8
Description: A polyclonal antibody raised in Rabbit that recognizes and binds to Human Caveolin-1 . This antibody is tested and proven to work in the following applications:

Caveolin 1 (CAV1) Polyclonal Antibody (Human, Mouse)
4-PAA214Hu01
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Description: A Rabbit polyclonal antibody against Human, Mouse Caveolin 1 (CAV1)

Caveolin-1 (V163) polyclonal antibody
E43S1043 100ul
EUR 225
Description: Available in various conjugation types.

Caveolin 2 (CAV2) pTyr27 rabbit polyclonal antibody, Aff - Purified
AP55796PU-N 100 µg Ask for price

Caveolin 2 (CAV2) pTyr27 rabbit polyclonal antibody, Aff - Purified
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Caveolin Polyclonal Antibody
40684 100ul
EUR 319

Caveolin 1 (CAV1) Polyclonal Antibody
CAU28340-100ul 100ul
EUR 229.4

Caveolin 1 (CAV1) Polyclonal Antibody
CAU28340-200ul 200ul
EUR 287.3

Caveolin 1 (CAV1) Polyclonal Antibody
CAU28341-100ul 100ul
EUR 217.9

Caveolin 1 (CAV1) Polyclonal Antibody
CAU28341-200ul 200ul
EUR 272.2

Caveolin 1 (CAV1) Polyclonal Antibody
CAU28342-100ul 100ul
EUR 212.2

Caveolin 1 (CAV1) Polyclonal Antibody
CAU28342-200ul 200ul
EUR 265.4

Caveolin 1 (CAV1) Polyclonal Antibody
CAU30985-100ul 100ul
EUR 232.3

Caveolin 1 (CAV1) Polyclonal Antibody
CAU30985-200ul 200ul
EUR 290.6

Caveolin 1 (CAV1) Polyclonal Antibody (Human, Mouse), PE
4-PAA214Hu01-PE
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Description: A Rabbit polyclonal antibody against Human, Mouse Caveolin 1 (CAV1). This antibody is labeled with PE.

Rabbit polyclonal Caveolin 2 (Tyr27) antibody(Phospho-specific)
TA313185 100 µl Ask for price

Caveolin 1 (CAV1) Polyclonal Antibody (Human, Mouse), APC
4-PAA214Hu01-APC
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Description: A Rabbit polyclonal antibody against Human, Mouse Caveolin 1 (CAV1). This antibody is labeled with APC.

Caveolin 1 (CAV1) Polyclonal Antibody (Human, Mouse), Cy3
4-PAA214Hu01-Cy3
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Description: A Rabbit polyclonal antibody against Human, Mouse Caveolin 1 (CAV1). This antibody is labeled with Cy3.

Caveolin 1 (CAV1) Polyclonal Antibody (Human, Mouse), HRP
4-PAA214Hu01-HRP
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  • 100ul
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Description: A Rabbit polyclonal antibody against Human, Mouse Caveolin 1 (CAV1). This antibody is labeled with HRP.

Caveolin 1 (CAV1) Polyclonal Antibody (Human, Mouse), FITC
4-PAA214Hu01-FITC
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  • 100ul
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Description: A Rabbit polyclonal antibody against Human, Mouse Caveolin 1 (CAV1). This antibody is labeled with FITC.

Caveolin 1 (CAV1) Polyclonal Antibody (Mouse)
4-PAA214Mu01
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Description: A Rabbit polyclonal antibody against Mouse Caveolin 1 (CAV1)

Caveolin-1 (phospho Tyr14) Polyclonal Antibody
E20-60050 100ug
EUR 225
Description: Available in various conjugation types.

Caveolin-1 (phospho Tyr14) Polyclonal Antibody
ABP50280-003ml 0.03ml
EUR 189.6
Description: A polyclonal antibody for detection of Caveolin-1 phospho Tyr14) from Human, Mouse, Rat. This Caveolin-1 phospho Tyr14) antibody is for WB, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from human Caveolin-1 around the phosphorylation site of Y14

Caveolin-1 (phospho Tyr14) Polyclonal Antibody
ABP50280-01ml 0.1ml
EUR 346.8
Description: A polyclonal antibody for detection of Caveolin-1 phospho Tyr14) from Human, Mouse, Rat. This Caveolin-1 phospho Tyr14) antibody is for WB, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from human Caveolin-1 around the phosphorylation site of Y14

Caveolin-1 (phospho Tyr14) Polyclonal Antibody
ABP50280-02ml 0.2ml
EUR 496.8
Description: A polyclonal antibody for detection of Caveolin-1 phospho Tyr14) from Human, Mouse, Rat. This Caveolin-1 phospho Tyr14) antibody is for WB, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from human Caveolin-1 around the phosphorylation site of Y14

Caveolin-1 (phospho Tyr14) Polyclonal Antibody
E44H00483 100ul
EUR 255
Description: Biotin-Conjugated, FITC-Conjugated , AF350 Conjugated , AF405M-Conjugated ,AF488-Conjugated, AF514-Conjugated ,AF532-Conjugated, AF555-Conjugated ,AF568-Conjugated , HRP-Conjugated, AF405S-Conjugated, AF405L-Conjugated , AF546-Conjugated, AF594-Conjugated , AF610-Conjugated, AF635-Conjugated , AF647-Conjugated , AF680-Conjugated , AF700-Conjugated , AF750-Conjugated , AF790-Conjugated , APC-Conjugated , PE-Conjugated , Cy3-Conjugated , Cy5-Conjugated , Cy5.5-Conjugated , Cy7-Conjugated Antibody

Caveolin-1 (CAV1) Goat anti-Human Polyclonal (Internal) Antibody
GWB-B18F13 0.05 mg Ask for price

Caveolin 1 (CAV1) Polyclonal Antibody (Human, Mouse), APC-Cy7
4-PAA214Hu01-APC-Cy7
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Description: A Rabbit polyclonal antibody against Human, Mouse Caveolin 1 (CAV1). This antibody is labeled with APC-Cy7.

Goat Polyclonal Antibody against Caveolin 1
TA302639 100 µg Ask for price

Caveolin 1 (CAV1) Polyclonal Antibody (Human, Mouse), Biotinylated
4-PAA214Hu01-Biotin
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Description: A Rabbit polyclonal antibody against Human, Mouse Caveolin 1 (CAV1). This antibody is labeled with Biotin.

Caveolin 1 (CAV1) Polyclonal Antibody (Mouse), PE
4-PAA214Mu01-PE
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  • 100ul
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Description: A Rabbit polyclonal antibody against Mouse Caveolin 1 (CAV1). This antibody is labeled with PE.

Polyclonal CAV2 / Caveolin 2 Antibody
APG01235G 0.1mg
EUR 580.8
Description: A polyclonal antibody raised in Goat that recognizes and binds to Human CAV2 / Caveolin 2 . This antibody is tested and proven to work in the following applications:

Caveolin 1 (CAV1) Polyclonal Antibody (Mouse), APC
4-PAA214Mu01-APC
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Description: A Rabbit polyclonal antibody against Mouse Caveolin 1 (CAV1). This antibody is labeled with APC.

Caveolin 1 (CAV1) Polyclonal Antibody (Mouse), Cy3
4-PAA214Mu01-Cy3
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  • 100ul
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Description: A Rabbit polyclonal antibody against Mouse Caveolin 1 (CAV1). This antibody is labeled with Cy3.

Caveolin 1 (CAV1) Polyclonal Antibody (Mouse), HRP
4-PAA214Mu01-HRP
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  • 100ul
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Description: A Rabbit polyclonal antibody against Mouse Caveolin 1 (CAV1). This antibody is labeled with HRP.

Caveolin 1 (CAV1) Polyclonal Antibody (Mouse, Rat)
4-PAA214Ra01
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Description: A Rabbit polyclonal antibody against Mouse, Rat Caveolin 1 (CAV1)

Polyclonal CAV1 / Caveolin 1 Antibody (Internal)
APG02439G 0.05mg
EUR 580.8
Description: A polyclonal antibody raised in Goat that recognizes and binds to Human CAV1 / Caveolin 1 (Internal). This antibody is tested and proven to work in the following applications:

Caveolin 1 (CAV1) Polyclonal Antibody (Mouse), FITC
4-PAA214Mu01-FITC
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Description: A Rabbit polyclonal antibody against Mouse Caveolin 1 (CAV1). This antibody is labeled with FITC.

Polyclonal CAV1 / Caveolin 1 Antibody (aa1-104)
APG02436G 0.05mg
EUR 580.8
Description: A polyclonal antibody raised in Rabbit that recognizes and binds to Human CAV1 / Caveolin 1 (aa1-104). This antibody is tested and proven to work in the following applications:

Polyclonal CAV1 / Caveolin 1 Antibody (aa2-104)
APG02438G 0.05mg
EUR 580.8
Description: A polyclonal antibody raised in Rabbit that recognizes and binds to Human CAV1 / Caveolin 1 (aa2-104). This antibody is tested and proven to work in the following applications:

Caveolin 1 (CAV1) Polyclonal Antibody (Mouse, Rat), PE
4-PAA214Ra01-PE
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  • 100ul
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Description: A Rabbit polyclonal antibody against Mouse, Rat Caveolin 1 (CAV1). This antibody is labeled with PE.

Polyclonal CAV1 / Caveolin 1 Antibody (aa129-178)
APG02437G 0.05ml
EUR 580.8
Description: A polyclonal antibody raised in Rabbit that recognizes and binds to Human CAV1 / Caveolin 1 (aa129-178). This antibody is tested and proven to work in the following applications:

Caveolin 1 (CAV1) Polyclonal Antibody (Mouse, Rat), APC
4-PAA214Ra01-APC
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  • 100ul
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Description: A Rabbit polyclonal antibody against Mouse, Rat Caveolin 1 (CAV1). This antibody is labeled with APC.

Caveolin 1 (CAV1) Polyclonal Antibody (Mouse, Rat), Cy3
4-PAA214Ra01-Cy3
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  • 100ul
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Description: A Rabbit polyclonal antibody against Mouse, Rat Caveolin 1 (CAV1). This antibody is labeled with Cy3.

Caveolin 1 (CAV1) Polyclonal Antibody (Mouse, Rat), HRP
4-PAA214Ra01-HRP
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  • 100ul
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  • 200ul
  • 20ul
Description: A Rabbit polyclonal antibody against Mouse, Rat Caveolin 1 (CAV1). This antibody is labeled with HRP.

Polyclonal CAV1 / Caveolin 1 Antibody (N-Terminus)
APG02440G 0.1mg
EUR 580.8
Description: A polyclonal antibody raised in Goat that recognizes and binds to Human CAV1 / Caveolin 1 (N-Terminus). This antibody is tested and proven to work in the following applications:

Polyclonal CAV1 / Caveolin 1 Antibody (N-Terminus)
APG02441G 0.05mg
EUR 580.8
Description: A polyclonal antibody raised in Rabbit that recognizes and binds to Human CAV1 / Caveolin 1 (N-Terminus). This antibody is tested and proven to work in the following applications:

Polyclonal CAV1 / Caveolin 1 Antibody (N-Terminus)
APG02442G 0.05mg
EUR 580.8
Description: A polyclonal antibody raised in Rabbit that recognizes and binds to Human CAV1 / Caveolin 1 (N-Terminus). This antibody is tested and proven to work in the following applications:

Caveolin-2 (phospho Tyr27) Polyclonal Antibody
13999 100ul
EUR 319

Caveolin-2 (phospho Tyr27) Polyclonal Antibody
E013999 100μg/100μl
EUR 255
Description: Available in various conjugation types.

Caveolin-2 (phospho Tyr27) Polyclonal Antibody
E20-60454 100ug
EUR 225
Description: Available in various conjugation types.

Caveolin-2 (phospho Tyr27) Polyclonal Antibody
ABP56829-003ml 0.03ml
EUR 189.6
Description: A polyclonal antibody for detection of Caveolin-2 phospho Tyr27) from Human. This Caveolin-2 phospho Tyr27) antibody is for WB, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from human Caveolin-2 around the phosphorylation site of Y27

Caveolin-2 (phospho Tyr27) Polyclonal Antibody
ABP56829-01ml 0.1ml
EUR 346.8
Description: A polyclonal antibody for detection of Caveolin-2 phospho Tyr27) from Human. This Caveolin-2 phospho Tyr27) antibody is for WB, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from human Caveolin-2 around the phosphorylation site of Y27

Caveolin-2 (phospho Tyr27) Polyclonal Antibody
ABP56829-02ml 0.2ml
EUR 496.8
Description: A polyclonal antibody for detection of Caveolin-2 phospho Tyr27) from Human. This Caveolin-2 phospho Tyr27) antibody is for WB, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from human Caveolin-2 around the phosphorylation site of Y27

Caveolin-2 (phospho Tyr27) Polyclonal Antibody
E44H00995 100ul
EUR 255
Description: Biotin-Conjugated, FITC-Conjugated , AF350 Conjugated , AF405M-Conjugated ,AF488-Conjugated, AF514-Conjugated ,AF532-Conjugated, AF555-Conjugated ,AF568-Conjugated , HRP-Conjugated, AF405S-Conjugated, AF405L-Conjugated , AF546-Conjugated, AF594-Conjugated , AF610-Conjugated, AF635-Conjugated , AF647-Conjugated , AF680-Conjugated , AF700-Conjugated , AF750-Conjugated , AF790-Conjugated , APC-Conjugated , PE-Conjugated , Cy3-Conjugated , Cy5-Conjugated , Cy5.5-Conjugated , Cy7-Conjugated Antibody

Caveolin 1 (CAV1) Polyclonal Antibody (Mouse, Rat), FITC
4-PAA214Ra01-FITC
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  • 100ul
  • 10ml
  • 1ml
  • 200ul
  • 20ul
Description: A Rabbit polyclonal antibody against Mouse, Rat Caveolin 1 (CAV1). This antibody is labeled with FITC.

Caveolin 1 (CAV1) Polyclonal Antibody (Mouse), APC-Cy7
4-PAA214Mu01-APC-Cy7
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  • 100ul
  • 10ml
  • 1ml
  • 200ul
  • 20ul
Description: A Rabbit polyclonal antibody against Mouse Caveolin 1 (CAV1). This antibody is labeled with APC-Cy7.

Caveolin 1 (CAV1) Polyclonal Antibody (Mouse), Biotinylated
4-PAA214Mu01-Biotin
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  • 100ul
  • 10ml
  • 1ml
  • 200ul
  • 20ul
Description: A Rabbit polyclonal antibody against Mouse Caveolin 1 (CAV1). This antibody is labeled with Biotin.

Caveolin 1 (CAV1) Polyclonal Antibody (Mouse, Rat), APC-Cy7
4-PAA214Ra01-APC-Cy7
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  • 100ul
  • 10ml
  • 1ml
  • 200ul
  • 20ul
Description: A Rabbit polyclonal antibody against Mouse, Rat Caveolin 1 (CAV1). This antibody is labeled with APC-Cy7.

Caveolin 1 (CAV1) Polyclonal Antibody (Mouse, Rat), Biotinylated
4-PAA214Ra01-Biotin
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  • 100ul
  • 10ml
  • 1ml
  • 200ul
  • 20ul
Description: A Rabbit polyclonal antibody against Mouse, Rat Caveolin 1 (CAV1). This antibody is labeled with Biotin.

Polyclonal CAV3 / Caveolin 3 Antibody (N-Terminus)
APG01183G 0.05mg
EUR 580.8
Description: A polyclonal antibody raised in Goat that recognizes and binds to Human CAV3 / Caveolin 3 (N-Terminus). This antibody is tested and proven to work in the following applications:

Caveolin 1 Rabbit Monoclonal Antibody
E10G20916 100 μl
EUR 275
Description: Biotin-Conjugated, FITC-Conjugated , AF350 Conjugated , AF405M-Conjugated ,AF488-Conjugated, AF514-Conjugated ,AF532-Conjugated, AF555-Conjugated ,AF568-Conjugated , HRP-Conjugated, AF405S-Conjugated, AF405L-Conjugated , AF546-Conjugated, AF594-Conjugated , AF610-Conjugated, AF635-Conjugated , AF647-Conjugated , AF680-Conjugated , AF700-Conjugated , AF750-Conjugated , AF790-Conjugated , APC-Conjugated , PE-Conjugated , Cy3-Conjugated , Cy5-Conjugated , Cy5.5-Conjugated , Cy7-Conjugated Antibody

Caveolin 1 Rabbit Monoclonal Antibody
E10G21170 100 μl
EUR 275
Description: Biotin-Conjugated, FITC-Conjugated , AF350 Conjugated , AF405M-Conjugated ,AF488-Conjugated, AF514-Conjugated ,AF532-Conjugated, AF555-Conjugated ,AF568-Conjugated , HRP-Conjugated, AF405S-Conjugated, AF405L-Conjugated , AF546-Conjugated, AF594-Conjugated , AF610-Conjugated, AF635-Conjugated , AF647-Conjugated , AF680-Conjugated , AF700-Conjugated , AF750-Conjugated , AF790-Conjugated , APC-Conjugated , PE-Conjugated , Cy3-Conjugated , Cy5-Conjugated , Cy5.5-Conjugated , Cy7-Conjugated Antibody

Caveolin 1 (CAV1) (Internal) goat polyclonal antibody, Aff - Purified
AP07517PU-N 50 µg Ask for price

Caveolin 2 (Phospho-Tyr27) Polyclonal Conjugated Antibody
C11778 100ul
EUR 476.4

Caveolin 2 (Phospho-Ser23) Polyclonal Conjugated Antibody
C12468 100ul
EUR 476.4

Caveolin 2 (Phospho-Ser36) Polyclonal Conjugated Antibody
C12469 100ul
EUR 476.4

Caveolin 2 Rabbit Monoclonal Antibody
E10G21171 100 μl
EUR 275
Description: Biotin-Conjugated, FITC-Conjugated , AF350 Conjugated , AF405M-Conjugated ,AF488-Conjugated, AF514-Conjugated ,AF532-Conjugated, AF555-Conjugated ,AF568-Conjugated , HRP-Conjugated, AF405S-Conjugated, AF405L-Conjugated , AF546-Conjugated, AF594-Conjugated , AF610-Conjugated, AF635-Conjugated , AF647-Conjugated , AF680-Conjugated , AF700-Conjugated , AF750-Conjugated , AF790-Conjugated , APC-Conjugated , PE-Conjugated , Cy3-Conjugated , Cy5-Conjugated , Cy5.5-Conjugated , Cy7-Conjugated Antibody

Anti-Caveolin 1/3(Caveolin 1+ Caveolin 3) Antibody
Y080094 100 µl
EUR 125

anti- Caveolin-1 antibody
FNab01313 100µg
EUR 606.3
Description: Antibody raised against Caveolin-1

anti- Caveolin-1 antibody
FNab01314 100µg
EUR 606.3
Description: Antibody raised against Caveolin-1

Anti-human Caveolin-1 antibody
A1506-50 each
EUR 561.6

Anti- Caveolin-1 (CAV1) Antibody
GWB-347445 0.1 mg Ask for price

Anti- Caveolin-1 (CAV1) Antibody
GWB-84CF33 0.05 mg Ask for price

Anti- Caveolin-1 (CAV1) Antibody
GWB-C2E1AD 0.05 mg Ask for price

Anti- Caveolin-1 (CAV1) Antibody
GWB-D4B933 0.05 mg Ask for price

Caveolin-1 Antibody
33331-100ul 100ul
EUR 302.4

Caveolin-1 Antibody
33331-50ul 50ul
EUR 224.4

Caveolin-1 Antibody
48674-100ul 100ul
EUR 399.6

Caveolin-1 Antibody
48674-50ul 50ul
EUR 286.8

Under menthol-flavored e-liquid remedy, MMP9 (matrix metallopeptidase 9), PTGS2 (prostaglandin-endoperoxide synthase 2), MYC (MYC proto-oncogene, bHLH transcription issue), HMOX1 (heme oxygenase 1), NOS3 (nitric oxide synthase 3), and CAV1 (caveolin 1) had been predicted as key genes. In addition, we recognized associated mobile processes, together with inflammatory responses, oxidative stress and carcinogenesis, underneath publicity to tobacco- and menthol-flavored e-liquids. We recognized differentially expressed genes and associated mobile processes and gene signaling pathways after e-cigarette publicity in human center ear cells. These findings could present helpful proof for understanding the impact of e-cigarette publicity.