Beta-catenin-mediated Wnt signal transduction proceeds through an endocytosis-independent mechanism.

The Wnt pathway is a key intercellular signaling cascade that regulates development, tissue homeostasis, and regeneration. However, gaps remain in our understanding of the molecular events that take place between ligand-receptor binding and target gene transcription. We used a novel tool for quantitative, real-time assessment of endogenous pathway activation, measured in single cells, to answer an unresolved question in the field – whether receptor endocytosis is required for Wnt signal transduction. We combined knockdown or knockout of essential components of Clathrin-mediated endocytosis with quantitative assessment of Wnt signal transduction in mouse embryonic stem cells (mESCs).

AGP Antibody
E561001-A-SE	EnoGene	100ug	EUR 295
Description: Available in various conjugation types.

AGP Antibody
MBS858222-01mg	MyBiosource	0.1mg	EUR 370

AGP Antibody
MBS858222-01mLAF405L	MyBiosource	0.1mL(AF405L)	EUR 565

AGP Antibody
MBS858222-01mLAF405S	MyBiosource	0.1mL(AF405S)	EUR 565

AGP Antibody
MBS858222-01mLAF610	MyBiosource	0.1mL(AF610)	EUR 565

AGP Antibody
MBS858222-01mLAF635	MyBiosource	0.1mL(AF635)	EUR 565

AGP antibody
MBS833231-10mL	MyBiosource	10mL	EUR 200

AGP antibody
MBS833231-5x10mL	MyBiosource	5x10mL	EUR 740

AGP antibody
MBS833451-10mL	MyBiosource	10mL	EUR 200

AGP antibody
MBS833451-5x10mL	MyBiosource	5x10mL	EUR 740

AGP antibody
20-S7931G000-S7	Fitzgerald Industries International	10 ml	Ask for price

AGP antibody
20-S0211G000-V0	Fitzgerald Industries International	10 ml	Ask for price

Alpha1-AGP/ Rat Alpha1- AGP ELISA Kit
ELA-E0816r	Lifescience Market	96 Tests	EUR 1063.2

Recombinant Mesobuthus martensii Neurotoxin BmK AGP-SYPU1 (AGP-SYPU1)
MBS1211595-002mgBaculovirus	MyBiosource	0.02mg(Baculovirus)	EUR 990

Recombinant Mesobuthus martensii Neurotoxin BmK AGP-SYPU1 (AGP-SYPU1)
MBS1211595-002mgEColi	MyBiosource	0.02mg(E-Coli)	EUR 550

Recombinant Mesobuthus martensii Neurotoxin BmK AGP-SYPU1 (AGP-SYPU1)
MBS1211595-002mgYeast	MyBiosource	0.02mg(Yeast)	EUR 740

Recombinant Mesobuthus martensii Neurotoxin BmK AGP-SYPU1 (AGP-SYPU1)
MBS1211595-01mgEColi	MyBiosource	0.1mg(E-Coli)	EUR 660

Recombinant Mesobuthus martensii Neurotoxin BmK AGP-SYPU1 (AGP-SYPU1)
MBS1211595-01mgYeast	MyBiosource	0.1mg(Yeast)	EUR 865

Recombinant Ascaris suum GTP-binding protein AGP-1 (AGP-1), partial
MBS1280459-INQUIRE	MyBiosource	INQUIRE	Ask for price

AGP-2 polyclonal antibody
BS60097	Bioworld Biotech	50ul	EUR 275
Description: Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Dog AGP ELISA Kit
E-40AGP	Immunology Consultants Laboratory	1 x 96 well plate	EUR 590.4

Cow AGP ELISA kit
AGP-11	Life Diagnostics	1x 96 wells plate	EUR 475

Rat AGP ELISA kit
AGP-2	Life Diagnostics	1x 96 wells plate	EUR 425

Dog AGP ELISA kit
AGP-4	Life Diagnostics	1x 96 wells plate	EUR 475

Cat AGP ELISA kit
AGP-8	Life Diagnostics	1x 96 wells plate	EUR 475

Pig AGP ELISA kit
AGP-9	Life Diagnostics	1x 96 wells plate	EUR 475

Cat AGP ELISA Kit
MBS564245-5x96Wells	MyBiosource	5x96Wells	EUR 2895

Cat AGP ELISA Kit
MBS564245-96Wells	MyBiosource	96Wells	EUR 630

a1-Acid Glycoprotein (Alpha-1-acid Glycoprotein, AGP 1, AGP1, AGP-1, AGP-A, Alpha-1-AGP, Orosomucoid 1, Orosomucoid-1, OMD 1, OMD-1, ORM, ORM1)
MBS609367-01mg	MyBiosource	0.1mg	EUR 880

a1-Acid Glycoprotein (Alpha-1-acid Glycoprotein, AGP 1, AGP1, AGP-1, AGP-A, Alpha-1-AGP, Orosomucoid 1, Orosomucoid-1, OMD 1, OMD-1, ORM, ORM1)
MBS609367-5x01mg	MyBiosource	5x0.1mg	EUR 3820

Mouse AGP ELISA kit
AGP-1	Life Diagnostics	1x 96 wells plate	EUR 475

Monkey AGP ELISA kit
AGP-3	Life Diagnostics	1x 96 wells plate	EUR 475

Turkey AGP ELISA kit
AGP-6	Life Diagnostics	1x 96 wells plate	EUR 450

Chicken AGP ELISA kit
AGP-5	Life Diagnostics	1x 96 wells plate	EUR 475

a1-Acid Glycoprotein 2 (Alpha-1-acid Glycoprotein 2, AGP 2, AGP2, AGP-B, AGP-B', Orosomucoid-2, OMD 2, ORM2)
MBS649444-005mg	MyBiosource	0.05mg	EUR 630

a1-Acid Glycoprotein 2 (Alpha-1-acid Glycoprotein 2, AGP 2, AGP2, AGP-B, AGP-B', Orosomucoid-2, OMD 2, ORM2)
MBS649444-5x005mg	MyBiosource	5x0.05mg	EUR 2680

Cow AGP SPARCL™ Assay
AGP-SP-11	Life Diagnostics	1 kit	EUR 400

Rat AGP SPARCL™ Assay
AGP-SP-2	Life Diagnostics	1 kit	EUR 500

Cat AGP SPARCL™ Assay
AGP-SP-8	Life Diagnostics	1 kit	EUR 500

Chicken AGP SPARCL™ Assay
AGP-SP-5	Life Diagnostics	1 kit	EUR 500

AGP ELISA Kit (Bovine) (OKCD06846)
OKCD06846	Aviva Systems Biology	96 Wells	EUR 1248
Description: Description of target: Functions as transport protein in the blood stream.UniRule annotation;Species reactivity: Bovine;Application: ELISA;Assay info: ;Sensitivity: < 7.0ng/mL

a1-Acid Glycoprotein I (Orosomucoid 1, AGP1, AGP 1, AGP-A, OMD 1, ORM, Orosomucoid-1)
MBS612230-005mL	MyBiosource	0.05mL	EUR 760

a1-Acid Glycoprotein I (Orosomucoid 1, AGP1, AGP 1, AGP-A, OMD 1, ORM, Orosomucoid-1)
MBS612230-5x005mL	MyBiosource	5x0.05mL	EUR 3265

OPCD00959-10UG - AGP Recombinant Protein
OPCD00959-10UG	Aviva Systems Biology	10ug	EUR 149

OPCD00959-50UG - AGP Recombinant Protein
OPCD00959-50UG	Aviva Systems Biology	50ug	EUR 379

OPCD00959-200UG - AGP Recombinant Protein
OPCD00959-200UG	Aviva Systems Biology	200ug	EUR 749

Arabinogalactan-Protein, AGP (monoclonal, JIM15)
AS22-4747	Agrisera AB	1 ml	EUR 246

Cat AGP ELISA Kit | E-20AGP
E-20AGP	Immunology Consultants Laboratory	Kit 1 x 96 well plate	EUR 760
Description: Cat AGP ELISA Kit ; E-20AGP ; Immunology Consultants Laboratory Species Reactivity: Cat Format: Sandwich ELISA Product Type: ELISA Kit Range: 1.57 ng/ml - 100 ng/ml

Rat AGP ELISA Kit | E-25AGP
E-25AGP	Immunology Consultants Laboratory	1 x 96 well plate	EUR 680
Description: Rat AGP ELISA Kit ; E-25AGP ; Immunology Consultants Laboratory Species Reactivity: Rat Format: Sandwich ELISA Product Type: ELISA Kit Range: 12.5 ng/ml - 400 ng/ml

Nori® Monkey AGP ELISA Kit
GR169206	Genorise Scientific	96-well	EUR 461

Nori® Ferret AGP ELISA Kit
GR201130	Genorise Scientific	96-well	EUR 461

Nori® Salmon AGP ELISA Kit
GR202130	Genorise Scientific	96-well	EUR 461

Human AGP ELISA Kit | E-80AGP
E-80AGP	Immunology Consultants Laboratory	1 x 96 well plate	EUR 570
Description: Human AGP ELISA Kit ; E-80AGP ; Immunology Consultants Laboratory Species Reactivity: Human Format: Sandwich ELISA Product Type: ELISA Kit Range: 5 ng/ml - 320 ng/ml

Nori® Hamster AGP ELISA Kit
GR172256	Genorise Scientific	96-well	EUR 461

Bovine AGP ELISA Kit | E-10AGP
E-10AGP	Immunology Consultants Laboratory	1 x 96 well plate	EUR 712
Description: Bovine AGP ELISA Kit ; E-10AGP ; Immunology Consultants Laboratory Species Reactivity: Bovine Format: Sandwich ELISA Product Type: ELISA Kit Range: 3.125 ng/ml - 100 ng/ml

Chicken AGP ELISA Kit | E-30AGP
E-30AGP	Immunology Consultants Laboratory	1 x 96 well plate	EUR 680
Description: Chicken AGP ELISA Kit ; E-30AGP ; Immunology Consultants Laboratory Species Reactivity: Chicken Format: Sandwich ELISA Product Type: ELISA Kit Range: 6.25 ng/ml - 200 ng/ml

Nori® Zebrafish AGP ELISA Kit
GR206130	Genorise Scientific	96-well	EUR 461

OKCD06846-96W - AGP ELISA Kit (Bovine)
OKCD06846-96W	Aviva Systems Biology	96Wells	EUR 850

Arabinogalactan-protein, AGP (monoclonal, clone LM2)
AS18-4211-1ml	Agrisera AB	1 ml	EUR 246

Arabinogalactan-Protein, AGP (monoclonal, clone JIM4)
AS22-4743	Agrisera AB	1 ml	EUR 246

Arabinogalactan-Protein, AGP (monoclonal, clone JIM8)
AS22-4744	Agrisera AB	1 ml	EUR 246

Arabinogalactan-Protein, AGP (monoclonal, clone LM14)
AS22-4746	Agrisera AB	1 ml	EUR 246

Arabinogalactan-Protein, AGP (monoclonal, clone LM30)
AS22-4749	Agrisera AB	1 ml	EUR 246

Arabinogalactan-Protein, AGP (monoclonal, clone JIM13)
AS22-4745	Agrisera AB	1 ml	EUR 246

Arabinogalactan-Protein, AGP (monoclonal, clone JIM16)
AS22-4748	Agrisera AB	1 ml	EUR 246

anti-α1-acid glycoprotein (AGP)(29A1)
LF-MA0167	Abfrontier	100 ul	EUR 400.8
Description: Mouse monoclonal to α1-acid glycoprotein (AGP)

1 AGP acyltransferase 4 (AGPAT4) rabbit polyclonal antibody
AP17875PU-N	Origene Technologies GmbH	400 µl	Ask for price

a1-Acid Glycoprotein (Alpha-1-acid Glycoprotein 1, AGP 1, AGP1, AGP-A, Orosomucoid-1, OMD 1, ORM1, Orosomucoid, ORM)
MBS648997-1mL	MyBiosource	1mL	EUR 525

a1-Acid Glycoprotein (Alpha-1-acid Glycoprotein 1, AGP 1, AGP1, AGP-A, Orosomucoid-1, OMD 1, ORM1, Orosomucoid, ORM)
MBS648997-5x1mL	MyBiosource	5x1mL	EUR 2210

Canine Alpha 1-Acid Glycoprotein (AGP) ELISA
GWB-374Z17	GenWay Biotech	96 well	Ask for price

Chicken Alpha 1-Acid Glycoprotein (AGP) ELISA
GWB-374Z11	GenWay Biotech	96 well	Ask for price

Recombinant Escherichia coli Glucose-1-phosphatase (agp)
MBS1009113-002mgBaculovirus	MyBiosource	0.02mg(Baculovirus)	EUR 1265

Recombinant Escherichia coli Glucose-1-phosphatase (agp)
MBS1009113-002mgEColi	MyBiosource	0.02mg(E-Coli)	EUR 935

Recombinant Escherichia coli Glucose-1-phosphatase (agp)
MBS1009113-002mgYeast	MyBiosource	0.02mg(Yeast)	EUR 1055

Recombinant Escherichia coli Glucose-1-phosphatase (agp)
MBS1009113-01mgEColi	MyBiosource	0.1mg(E-Coli)	EUR 1125

Recombinant Escherichia coli Glucose-1-phosphatase (agp)
MBS1009113-01mgYeast	MyBiosource	0.1mg(Yeast)	EUR 1200

Recombinant Providencia rettgeri Glucose-1-phosphatase (agp)
MBS1367268-002mgBaculovirus	MyBiosource	0.02mg(Baculovirus)	EUR 1265

Recombinant Providencia rettgeri Glucose-1-phosphatase (agp)
MBS1367268-002mgEColi	MyBiosource	0.02mg(E-Coli)	EUR 935

Recombinant Providencia rettgeri Glucose-1-phosphatase (agp)
MBS1367268-002mgYeast	MyBiosource	0.02mg(Yeast)	EUR 1060

Recombinant Providencia rettgeri Glucose-1-phosphatase (agp)
MBS1367268-01mgEColi	MyBiosource	0.1mg(E-Coli)	EUR 1125

Recombinant Providencia rettgeri Glucose-1-phosphatase (agp)
MBS1367268-01mgYeast	MyBiosource	0.1mg(Yeast)	EUR 1205

Recombinant Salmonella typhimurium Glucose-1-phosphatase (agp)
MBS1117538-002mgBaculovirus	MyBiosource	0.02mg(Baculovirus)	EUR 1265

Recombinant Salmonella typhimurium Glucose-1-phosphatase (agp)
MBS1117538-002mgEColi	MyBiosource	0.02mg(E-Coli)	EUR 935

Recombinant Salmonella typhimurium Glucose-1-phosphatase (agp)
MBS1117538-002mgYeast	MyBiosource	0.02mg(Yeast)	EUR 1055

Recombinant Salmonella typhimurium Glucose-1-phosphatase (agp)
MBS1117538-01mgEColi	MyBiosource	0.1mg(E-Coli)	EUR 1125

Recombinant Salmonella typhimurium Glucose-1-phosphatase (agp)
MBS1117538-01mgYeast	MyBiosource	0.1mg(Yeast)	EUR 1200

Human ?1-Acid glycoprotein,?1-AGP ELISA Kit
201-12-1776	Shanghai Sunred Biological Technology	96 tests	EUR 528
Description: A quantitative ELISA kit for measuring Human in samples from biological fluids.

Rat α1-Acid glycoprotein(α1-AGP) ELISA Kit
CSB-E12730r-48T	Cusabio	48T	EUR 290.06
Description: Rattus norvegicus (Rat)

Rat α1-Acid glycoprotein(α1-AGP) ELISA Kit
CSB-E12730r-96T	Cusabio	96T	EUR 446.25
Description: Rattus norvegicus (Rat)

Rat α1-Acid glycoprotein(α1-AGP)ELISA Kit
GA-E0093RT-48T	GenAsia Biotech	48T	EUR 380.4

Rat α1-Acid glycoprotein(α1-AGP)ELISA Kit
GA-E0093RT-48Tests	GenAsia Biotech	48 Tests	Ask for price

Rat α1-Acid glycoprotein(α1-AGP)ELISA Kit
GA-E0093RT-96T	GenAsia Biotech	96T	EUR 595.2

Rat α1-Acid glycoprotein(α1-AGP)ELISA Kit
GA-E0093RT-96Tests	GenAsia Biotech	96 Tests	EUR 420

Rat α1-Acid glycoprotein(α1-AGP) ELISA Kit
EKC42303-48T	Biomatik Corporation	48T	EUR 474.04

Rat α1-Acid glycoprotein(α1-AGP) ELISA Kit
EKC42303-5x96T	Biomatik Corporation	5x96T	EUR 3216.7

Rat α1-Acid glycoprotein(α1-AGP) ELISA Kit
EKC42303-96T	Biomatik Corporation	96T	EUR 677.2

Rat α1-Acid glycoprotein(α1-AGP) Elisa Kit
EK720917	AFG Bioscience LLC	96 Wells	EUR 0.62

Rat α1-AGP(α1-Acid Glycoprotein) ELISA Kit
ER1432	FN Test	96T	EUR 628.92
Description: Method of detection: Double Antibody, Sandwich ELISA;Reacts with: Rattus;Sensitivity: 3.75 ng/ml

Bovine Orosomucoid 1,ORM1/α1-AGP ELISA Kit
YLA0129BO-48T	Shanghai YL Biotech	48T	Ask for price

Bovine Orosomucoid 1,ORM1/α1-AGP ELISA Kit
YLA0129BO-96T	Shanghai YL Biotech	96T	Ask for price

Rabbit Orosomucoid 1,ORM1/α1-AGP ELISA Kit
YLA0199RB-48T	Shanghai YL Biotech	48T	Ask for price

Rabbit Orosomucoid 1,ORM1/α1-AGP ELISA Kit
YLA0199RB-96T	Shanghai YL Biotech	96T	Ask for price

Rat α1-Acid glycoprotein,α1-AGP ELISA Kit
YLA0580RA-48T	Shanghai YL Biotech	48T	Ask for price

Rat α1-Acid glycoprotein,α1-AGP ELISA Kit
YLA0580RA-96T	Shanghai YL Biotech	96T	Ask for price

Rat α1-Acid glycoprotein,α1-AGP ELISA Kit
CN-01787R1	ChemNorm	96T	EUR 567.6

Rat α1-Acid glycoprotein,α1-AGP ELISA Kit
CN-01787R2	ChemNorm	48T	EUR 387.6

GOAT α1-Acid glycoprotein(α1-AGP)ELISA Kit
YLA0043GO-48T	Shanghai YL Biotech	48T	Ask for price

GOAT α1-Acid glycoprotein(α1-AGP)ELISA Kit
YLA0043GO-96T	Shanghai YL Biotech	96T	Ask for price

Mouse α1-AGP(α1-Acid glycoprotein) ELISA Kit
EM1448	FN Test	96T	EUR 628.92
Description: Method of detection: Double Antibody, Sandwich ELISA;Reacts with: Mus ;Sensitivity: 3.75 ng/ml

Human α1-Acid glycoprotein(α1-AGP)ELISA Kit
GA-E1792HM-48T	GenAsia Biotech	48T	EUR 346.8

Disruption of Clathrin-mediated endocytosis did not affect accumulation and nuclear translocation of β-catenin, as measured by single-cell live imaging of endogenous β-catenin, and subsequent target gene transcription. Disruption of another receptor endocytosis pathway, Caveolin-mediated endocytosis, did not affect Wnt pathway activation in mESCs. Additional results in multiple cell lines support that endocytosis is not a requirement for Wnt signal transduction. We show that off-target effects of a drug used to inhibit endocytosis may be one source of the discrepancy among reports on the role of endocytosis in Wnt signaling.