The Wnt pathway is a key intercellular signaling cascade that regulates development, tissue homeostasis, and regeneration. However, gaps remain in our understanding of the molecular events that take place between ligand-receptor binding and target gene transcription. We used a novel tool for quantitative, real-time assessment of endogenous pathway activation, measured in single cells, to answer an unresolved question in the field – whether receptor endocytosis is required for Wnt signal transduction. We combined knockdown or knockout of essential components of Clathrin-mediated endocytosis with quantitative assessment of Wnt signal transduction in mouse embryonic stem cells (mESCs).


E-25AGP 1 x 96 well plate
EUR 441

Chicken AGP ELISA Kit

E-30AGP 1 x 96 well plate
EUR 441


E-40AGP 1 x 96 well plate
EUR 492


E-80AGP 1 x 96 well plate
EUR 370

IL-8 (-5 to +5)

5-01377 4 x 5mg Ask for price

Sheep A1-AGP ELISA Kit

ESA0695 96Tests
EUR 521

Mouse A1-AGP ELISA Kit

EMA0695 96Tests
EUR 521

Monkey A1-AGP ELISA Kit

EMKA0695 96Tests
EUR 521

Porcine A1-AGP ELISA Kit

EPA0695 96Tests
EUR 521


ERA0695 96Tests
EUR 521

Rabbit A1-AGP ELISA Kit

ERTA0695 96Tests
EUR 521

Anserini A1-AGP ELISA Kit

EAA0695 96Tests
EUR 521


EGTA0695 96Tests
EUR 521

Canine A1-AGP ELISA Kit

ECA0695 96Tests
EUR 521

Chicken A1-AGP ELISA Kit

ECKA0695 96Tests
EUR 521

Human A1-AGP ELISA Kit

EHA0695 96Tests
EUR 521

Bovine A1-AGP ELISA Kit

EBA0695 96Tests
EUR 521

AGP ELISA Kit (Bovine) (OKCD06846)

OKCD06846 96 Wells
EUR 1040
Description: Description of target: Functions as transport protein in the blood stream.UniRule annotation;Species reactivity: Bovine;Application: ELISA;Assay info: ;Sensitivity: < 7.0ng/mL


C4119-5 5 mg
EUR 118
Description: 2',3',5'-triacetyl-5-Azacytidine (TAC) is the lead prodrug form of 5-azacytidine which may be rapidly absorbed after oral administration [1]. 5-Azacytidine is an inhibitor of DNA methyltransferase [2].


EUR 153

Histatin 5

5-01307 4 x 1mg Ask for price


A3125-5 5 mg
EUR 168
Description: 5-Iodotubercidin (Itu) is a purine derivative and hence an inhibitor of adenosine kinase with an IC50 value of 26 nM [1]. Adenosine kinase is important in regulating the intracellular and extracellular concentrations of adenosine and hence diverse physiological actions of adenosine [2].


B8212-5 5 mg
EUR 195


EUR 142


EUR 126


EUR 457


EUR 153

Guinea Pig A1-AGP ELISA Kit

EGA0695 96Tests
EUR 521

Thrombin Receptor Activator for Peptide 5 (TRAP-5)

A1036-5 5 mg
EUR 102
Description: Thrombin Receptor Activator for Peptide 5 (TRAP-5),(C30H50N8O7), a peptide with the sequence NH2-Ser-Phe-Leu-Leu-Arg-COOH, MW= 634.76. coagulation factor II (thrombin) receptor is a G protein-coupled receptor involved in the regulation of thrombotic response.

TRAP-5 amide

5-02019 4 x 5mg Ask for price


5-00062 4 x 5mg Ask for price


5-00524 4 x 5mg Ask for price


5-00605 4 x 5mg Ask for price

Angiotensin (1-5)

5-00676 4 x 5mg Ask for price

Bradykinin (1-5)

5-00852 4 x 5mg Ask for price

W-5 hydrochloride

B6277-5 5 mg
EUR 116

5-Nonyloxytryptamine oxalate

B6496-5 5 mg
EUR 154

5'-deoxy Thymidine

C4692-5 5 mg
EUR 180
Description: 5'-Deoxy Thymidine has been used as a research tool for antiviral and anticancer studies. 5'-Deoxy Thymidine can be used to study the entry mechanism into human erythrocytes in comparison with other deoxythymidines.

Teicoplanin A2-5

C4938-5 5 mg
EUR 1157
Description: Teicoplanin A2-5, derived from Actinoplanes teichomyceticus, is a glycopeptide antibiotic which produces a broad spectrum of antibiotic activity against gram-positive bacteria.

5-fluoro 203

C4114-5 5 mg
EUR 154
Description: 5-fluoro 203 (5F-203) is an antitumor agent and cytotoxic compound that acts as a potent AhR agonist [1][2][3]. The aryl hydrocarbon receptor (AhR) is a ligand-activated transcription factor involved in regulating xenobiotic-metabolizing enzymes such as cytochrome P450.


EUR 240

5-Formylcytosine (5-fC) ELISA Kit

MET-5102-5 5 x 96 assays
EUR 2283

5-Carboxylcytosine (5-caC) ELISA Kit

MET-5103-5 5 x 96 assays
EUR 2283

Secretin (5 - 27), porcine

5-01917 4 x 1mg Ask for price

SH2 Domain Ligand (5)

5-01929 4 x 5mg Ask for price


5-04607 25g Ask for price


5-04608 100g Ask for price


5-04609 5g Ask for price


5-04610 25g Ask for price

Dok- 5 (263 - 275)

5-01048 4 x 5mg Ask for price


C4645-5 5 mg
EUR 128

2',5'-dideoxy Adenosine

C3993-5 5 mg
EUR 189
Description: 2',5'-dideoxy Adenosine, a nucleoside analog, is one of the first identified cell-permeable, P-site inhibitors of adenylate cyclase [1]. Adenylyl cyclase is an enzyme with key regulatory roles in almost all cells.

FAM azide, 5- isomer

A8117-5 5 mg
EUR 166
Description: FAM azide for Click chemistry labeling. FAM remains one of the most popular fluorescent lablels for various application. Most instruments capable of fluorescence detection, ranging from plate readers to fluorescence microscopes, are able to work in FAM channel.

ROX azide, 5- isomer

A8126-5 5 mg
EUR 583
Description: ROX (rhodamine-X) azide, solid material, and 10 mM solution in DMSO, labeling reagent for Click Chemistry. ROX is a red-emitting rhodamine dye possessing high brightness and fluorescence quantum yield.Pure 5-isomer.

TAMRA azide, 5- isomer

A8129-5 5 mg
EUR 583
Description: TAMRA (TMR, tetramethylrhodamine) azide, solid compound, and 10 mM solution in DMSO, labeling reagent for Click Chemistry. Pure 5-isomer.TAMRA is often used as FRET acceptor for FAM fluorophore.

5-trans U-46619

C4261-5 5 mg
EUR 538
Description: 5-trans U-46619 is a minor impurity (2-5%) which variably exists in most commercial preparations of U-46619 [1]. U-46619 is a selective thromboxane A2 agonist involved in inducing platelet aggregation and vascular smooth muscle contraction [2].

Individual Reaction Mix 5

G065-5 200 reactions
EUR 167


EUR 109

AICA riboside, 5'-phosphate

EUR 153

Necrosis Inhibitor, Necrox-5

EUR 615

Alpha 1 Acid Glycoprotein (A1-AGP), bovine

A1AG20-N 1 mg
EUR 164

Alpha 1 Acid Glycoprotein (A1-AGP), Rabbit

A1AG23-N-25 25 ug
EUR 286

Alpha 1 Acid Glycoprotein (A1-AGP), Turkey

A1AG24-N-100 100 ug
EUR 164

anti-α1-acid glycoprotein (AGP)(29A1)

LF-MA0167 100 ul
EUR 334
Description: Mouse monoclonal to α1-acid glycoprotein (AGP)


5-06939 5g Ask for price


5-06940 25g Ask for price

[Pyr5]-Substance P (5-11)

5-00288 4 x 5mg Ask for price

[Trp3, Arg5]-Ghrelin (1-5)

5-00313 4 x 5mg Ask for price

beta-Casomorphin (1-5) (bovine)

5-00475 4 x 5mg Ask for price

Angiotensin I/II (5-8)

5-00684 4 x 5mg Ask for price

Cholecystokinin Octapeptide (1-5) (desulfated)

5-00970 4 x 5mg Ask for price

HIV-gp41-Antigenic Peptide 5

5-01331 4 x 1mg Ask for price

Magnetic Beads (DNA) 5 mL

P920-5 - Ask for price

Angiotensin 1/2 (1-5)

A1047-5 5 mg
EUR 119
Description: Angiotensin I/II (1-5) is a peptide (ASP-ARG-VAL-TYR-ILE) that contains the amino acids 1-5 and is converted from Angiotensin I/II.Angiotensin I is formed by the action ofreninonangiotensinogen, an ?-2-globulin with 12 amino acids.

Angiotensin 1/2 (5-7)

A1049-5 5 mg
EUR 119
Description: Angiotensin 1/2 (5-7), (C17H27N5O4), a peptide with the sequence H2N-Ile-His-Pro-OH, MW=365.43. Angiotensin is a peptide hormone that causes vasoconstriction and a subsequent increase in blood pressure.

Helioxanthin derivative 5-4-2

B4700-5 5 mg
EUR 683
Description: Helioxanthin derivative 5-4-2, an analogue of helioxanthin (ACH126447), is a small-molecule inhibitor of HBV, HSV-1and HSV-2 virus with EC50 values of 0.08 ?M, 0.29 ?M and 0.16 ?M, respectively [1].


B7993-.5 5x100 µl (100 mM)
EUR 14023


B8035-.5 5x100 µl (100 mM)
EUR 2059


C5014-5 5 mg
EUR 134
Description: 3,3',5'-triiodo-L-thyronine (reverse T3 or rT3) and 3,5,3'-triiodo-L-thyronine (T3) are the metabolism of thyroxine (T4) [1]. 3,3',5'-Triiodo-L-thyronine is thyroid hormone receptors TR? and TR? antagonist [1].

5?-dihydro-11-keto Testosterone

C4317-5 5 mg
EUR 586
Description: 5?-dihydro-11-keto Testosterone (11KDHT) is a full androgen receptor agonist comparable to dihydrotestosterone (DHT) [1][2][3].


EUR 229

2-Methyl-5-hydroxytryptamine hydrochloride

EUR 185

pLenti-CLDN1 shRNA-5 Plasmid

PVTBAV04867-5 2 ug
EUR 356

Porcine α1-Acid glycoprotein,α1-AGP ELISA Kit

GA-E0068PC-48T 48T
EUR 364

Porcine α1-Acid glycoprotein,α1-AGP ELISA Kit

GA-E0068PC-96T 96T
EUR 590

Rat α1-Acid glycoprotein(α1-AGP)ELISA Kit

GA-E0093RT-48T 48T
EUR 317

Rat α1-Acid glycoprotein(α1-AGP)ELISA Kit

GA-E0093RT-96T 96T
EUR 496

Human α1-Acid glycoprotein(α1-AGP)ELISA Kit

GA-E1792HM-48T 48T
EUR 289

Human α1-Acid glycoprotein(α1-AGP)ELISA Kit

GA-E1792HM-96T 96T
EUR 466

Human ?1-Acid glycoprotein,?1-AGP ELISA Kit

201-12-1776 96 tests
EUR 440
Description: A quantitative ELISA kit for measuring Human in samples from biological fluids.

Human Alpha-1-Acid-Glycoprotein (Orosomucoid, AGP) Antibody

12011-05011 150 ug
EUR 217

Human alpha-1-Acid-Glycoprotein (Orosomucoid, AGP) Antibody

32220-05111 150 ug
EUR 261

Alpha 1 Acid Glycoprotein (A1-AGP), Human Plasma

A1AG15-N 1 mg
EUR 164

Mouse α1-AGP(α1-Acid glycoprotein) ELISA Kit

EM1448 96T
EUR 524.1
Description: Method of detection: Double Antibody, Sandwich ELISA;Reacts with: Mus ;Sensitivity: 3.75 ng/ml

Porcine α1-AGP(α1-Acid Glycoprotein) ELISA Kit

EP0214 96T
EUR 567.6
Description: Method of detection: Double Antibody, Sandwich ELISA;Reacts with: Pig;Sensitivity: 0.094 ng/ml

Rat α1-Acid glycoprotein(α1-AGP)ELISA Kit

QY-E11560 96T
EUR 361

Disruption of Clathrin-mediated endocytosis did not affect accumulation and nuclear translocation of β-catenin, as measured by single-cell live imaging of endogenous β-catenin, and subsequent target gene transcription. Disruption of another receptor endocytosis pathway, Caveolin-mediated endocytosis, did not affect Wnt pathway activation in mESCs. Additional results in multiple cell lines support that endocytosis is not a requirement for Wnt signal transduction. We show that off-target effects of a drug used to inhibit endocytosis may be one source of the discrepancy among reports on the role of endocytosis in Wnt signaling.