Non-alcoholic fatty liver illness (NAFLD) is related to weight problems, insulin resistance and dyslipidaemia and at present is estimated to have an effect on as much as a 3rd of all people in developed nations. Current commonplace of look after sufferers varies in accordance with illness stage, however consists of way of life interventions frequent insulin sensitizers, antioxidants and lipid modifiers. However, so far particular therapies have proven little histological or fibrosis stage enchancment in giant scientific trials, and there may be nonetheless no licensed remedy for NAFLD. Given the excessive prevalence, restricted remedy choices and important screening prices for the general inhabitants, new therapies are urgently required.
To assess the potential for inhibition of the amine oxidase enzyme vascular adhesion protein-1 (VAP-1) to change hepatic lipid accumulation in NAFLD. We have used immunochemical and qPCR evaluation to doc expression of VAP-1 and key practical proteins and transporters throughout the NAFLD spectrum. We then utilised hepatocytes in tradition and human precision reduce liver slices in live performance with selective enzyme exercise inhibitors to check the consequences of activating the semicarbazide-sensitive amine oxidase exercise of VAP-1 on hepatic lipid uptake and triglyceride export.
We confirmed that growing severity of NAFLD and development to cirrhosis was related to a big enhance in hepatocellular VAP-1 expression. Hepatocytes in vitro uncovered to recombinant VAP-1 and its substrate methylamine confirmed elevated lipid accumulation as decided by quantification of Oil Red O uptake. This was recapitulated utilizing hydrogen peroxide, and lipid accumulation was accompanied by adjustments in expression of the lipid transporter molecules FABP3, FATP6, insulin receptor subunits and PPARα.
Human liver tissue uncovered to recombinant VAP-1 or substrates for endo/exogenous VAP-1 produced much less triglyceride than untreated tissue and demonstrated a rise in steatosis. This response may very well be inhibited through the use of bromoethylamine to inhibit the SSAO exercise of VAP-1, and mice poor in VAP-1/AOC3 additionally demonstrated diminished steatosis on excessive fats weight loss plan. Exposure of human liver tissue to methylamine to activate VAP-1 resulted in elevated expression of FABP2 and 4, FATP3-5, caveolin-1, VLDLR, PPARGC1 and genes related to the inflammatory response.
Our information verify that the elevations in hepatic VAP-1 expression reported in nonalcoholic steatohepatitis can contribute to steatosis, metabolic disturbance and irritation. This means that concentrating on the semicarbazide delicate amine oxidase capability of VAP-1 could symbolize a helpful adjunct to different therapeutic methods in NAFLD. A murine mannequin of NAFLD was additionally used to find out the results of VAP-1 knockout and gene expression arrays had been used to quantify the consequences of VAP-1 exercise on key lipid modifying and proinflammatory gene expression.
Autophagy alleviates hypoxia-induced blood-brain barrier damage through regulation of CLDN5 (claudin 5)
Blood-brain barrier (BBB) disruption is a key occasion in triggering secondary harm to the central nervous system (CNS) underneath stroke, and is often related to irregular macroautophagy/autophagy in mind microvascular endothelial cells (BMECs). However, the underlying mechanism of autophagy in sustaining BBB integrity stays unclear. Here we report that in BMECs of sufferers struggling stroke, CLDN5 (claudin 5) abnormally aggregates in the cytosol accompanied by autophagy activation. In vivo zebrafish and in vitro cell research reveal that BBB breakdown is partially attributable to CAV1 (caveolin 1)-mediated redistribution of membranous CLDN5 into the cytosol underneath hypoxia.
Meanwhile, autophagy is activated and contributes primarily to the degradation of CAV1 and aggregated CLDN5 in the cytosol of BMECs, due to this fact assuaging BBB breakdown. Blockage of autophagy by genetic strategies or chemical compounds aggravates cytosolic aggregation of CLDN5, ensuing in severer BBB impairment. These information display that autophagy capabilities in the safety of BBB integrity by regulating CLDN5 redistribution and present a possible therapeutic technique for BBB disorder-related cerebrovascular illness.
BBB: blood-brain barrier; BECN1: beclin 1; BMEC: mind microvascular endothelial cell; CAV1: caveolin 1; CCA: frequent carotid artery; CLDN5: claudin 5; CNS: central nervous system; CQ: chloroquine; HIF1A: hypoxia inducible issue 1 subunit alpha; MCAO: center cerebral artery occlusion-reperfusion; OCLN: occludin; ROS: reactive oxygen species; STED: stimulated emission depletion; TEER: trans-endothelial electrical resistance; TEM: transmission electron microscopy; TJ: tight junction; TJP1: tight junction protein 1; UPS: ubiquitin-proteasome system.
Transcriptomic evaluation of tobacco-flavored E-cigarette and menthol-flavored E-cigarette publicity in the human center ear
Electronic cigarettes (e-cigarettes) are essentially the most broadly used digital nicotine supply techniques and are designed to mimic smoking and help in smoking cessation. Although the quantity of e-cigarette customers is growing quickly, particularly amongst younger adults and adolescents, the potential well being impacts and biologic results of e-cigarettes nonetheless have to be elucidated. Our earlier research demonstrated the cytotoxic results of digital liquids (e-liquids) in a human center ear epithelial cell (HMEEC-1) line, which had been affected by the producer and flavoring brokers regardless of the presence of nicotine.
In this research, we aimed to judge the gene expression profile and determine potential molecular modulator genes and pathways in HMEEC-1 uncovered to 2 completely different e-liquids (tobacco- and menthol-flavored). HMEEC-1 was uncovered to e-liquids, and RNA sequencing, practical evaluation, and pathway evaluation had been performed to determine the resultant transcriptomic adjustments. A complete of 843 genes had been differentially expressed following publicity to the tobacco-flavored e-liquid, amongst which 262 genes had been upregulated and 581 had been downregulated.
Upon publicity to the menthol-flavored e-liquid, a complete of 589 genes had been differentially expressed, amongst which 228 genes had been upregulated and 361 had been downregulated. Among the signaling pathways related to the differentially expressed genes mediated by tobacco-flavored e-liquid publicity, a number of key molecular genes had been recognized, together with IL6 (interleukin 6), PTGS2 (prostaglandin-endoperoxide synthase 2), CXCL8 (C-X-C motif chemokine ligand 8), JUN (Jun proto-oncogene), FOS (Fos proto-oncogene), and TP53 (tumor protein 53).
 Polyclonal Goat Anti-Caveolin 1 Antibody |
|
AMM04925G |
Leading Biology |
0.1 mg |
EUR 484 |
|
Description: A polyclonal antibody raised in Goat that recognizes and binds to Human Goat Anti-Caveolin 1 . This antibody is tested and proven to work in the following applications: |
 Anti-human Caveolin-1 antibody |
|
A1506-50 |
Biovision |
|
EUR 468 |
 Anti-Caveolin-1 antibody |
|
STJ92050 |
St John's Laboratory |
200 µl |
EUR 197 |
|
Description: Rabbit polyclonal to Caveolin-1. |
Anti-Caveolin-1 antibody |
|
STJ92051 |
St John's Laboratory |
200 µl |
EUR 197 |
|
Description: Caveolin-1 is a protein encoded by the CAV1 gene which is approximately 20,4 kDa. Caveolin-1 is localised to the Golgi apparatus membrane and cell membrane. It is involved in eNOS activation and regulation, focal adhesion and lipoprotein metabolism. It is a scaffolding protein that makes up the main component of the caveolae plasma membranes found in most cell types. The protein links integrin subunits to the tyrosine kinase FYN which is an initiating step in coupling integrins to the Ras-ERK pathway and promoting cell cycle progression. Caveolin-1 is expressed in the brain. Mutations in the CAV1 gene may result in pulmonary hypertension and lipodystrophy. STJ92051 was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. This polyclonal antibody detects endogenous levels of Caveolin-1 protein. |
 anti- Caveolin-1 antibody |
|
FNab01313 |
FN Test |
100µg |
EUR 505.25 |
|
|
|
Description: Antibody raised against Caveolin-1 |
anti- Caveolin-1 antibody |
|
FNab01314 |
FN Test |
100µg |
EUR 505.25 |
|
|
|
Description: Antibody raised against Caveolin-1 |
 Polyclonal Goat anti-GST α-form |
|
GST-ANTI-1 |
Detroit R&D |
50 uL |
EUR 280 |
 Caveolin-1 Polyclonal Antibody |
|
ES1872-100ul |
ELK Biotech |
100ul |
EUR 279 |
|
Description: A Rabbit Polyclonal antibody against Caveolin-1 from Human/Mouse/Rat. This antibody is tested and validated for WB, ELISA, WB, ELISA |
Caveolin-1 Polyclonal Antibody |
|
ES1872-50ul |
ELK Biotech |
50ul |
EUR 207 |
|
Description: A Rabbit Polyclonal antibody against Caveolin-1 from Human/Mouse/Rat. This antibody is tested and validated for WB, ELISA, WB, ELISA |
Caveolin-1 Polyclonal Antibody |
|
ES1873-100ul |
ELK Biotech |
100ul |
EUR 279 |
|
Description: A Rabbit Polyclonal antibody against Caveolin-1 from Human/Mouse/Rat. This antibody is tested and validated for WB, ELISA, IHC, IF, WB, ELISA |
Caveolin-1 Polyclonal Antibody |
|
ES1873-50ul |
ELK Biotech |
50ul |
EUR 207 |
|
Description: A Rabbit Polyclonal antibody against Caveolin-1 from Human/Mouse/Rat. This antibody is tested and validated for WB, ELISA, IHC, IF, WB, ELISA |
Caveolin-1 Polyclonal Antibody |
|
ABP50873-003ml |
Abbkine |
0.03ml |
EUR 158 |
|
|
|
Description: A polyclonal antibody for detection of Caveolin-1 from Human, Mouse, Rat. This Caveolin-1 antibody is for WB, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from human Caveolin-1 around the non-phosphorylation site of Y14 |
Caveolin-1 Polyclonal Antibody |
|
ABP50873-01ml |
Abbkine |
0.1ml |
EUR 289 |
|
|
|
Description: A polyclonal antibody for detection of Caveolin-1 from Human, Mouse, Rat. This Caveolin-1 antibody is for WB, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from human Caveolin-1 around the non-phosphorylation site of Y14 |
Caveolin-1 Polyclonal Antibody |
|
ABP50873-02ml |
Abbkine |
0.2ml |
EUR 414 |
|
|
|
Description: A polyclonal antibody for detection of Caveolin-1 from Human, Mouse, Rat. This Caveolin-1 antibody is for WB, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from human Caveolin-1 around the non-phosphorylation site of Y14 |
Caveolin-1 Polyclonal Antibody |
|
ABP50874-003ml |
Abbkine |
0.03ml |
EUR 158 |
|
|
|
Description: A polyclonal antibody for detection of Caveolin-1 from Human, Mouse, Rat. This Caveolin-1 antibody is for WB, IHC-P, IF, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from the C-terminal region of human Caveolin-1 at AA range: 100-180 |
Caveolin-1 Polyclonal Antibody |
|
ABP50874-01ml |
Abbkine |
0.1ml |
EUR 289 |
|
|
|
Description: A polyclonal antibody for detection of Caveolin-1 from Human, Mouse, Rat. This Caveolin-1 antibody is for WB, IHC-P, IF, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from the C-terminal region of human Caveolin-1 at AA range: 100-180 |
Caveolin-1 Polyclonal Antibody |
|
ABP50874-02ml |
Abbkine |
0.2ml |
EUR 414 |
|
|
|
Description: A polyclonal antibody for detection of Caveolin-1 from Human, Mouse, Rat. This Caveolin-1 antibody is for WB, IHC-P, IF, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from the C-terminal region of human Caveolin-1 at AA range: 100-180 |
Caveolin-1 Polyclonal Antibody |
|
40684-100ul |
SAB |
100ul |
EUR 252 |
Caveolin-1 Polyclonal Antibody |
|
40684-50ul |
SAB |
50ul |
EUR 187 |
 Polyclonal Caveolin-1 Antibody |
|
APG02445G |
Leading Biology |
0.05ml |
EUR 528 |
|
Description: A polyclonal antibody raised in Rabbit that recognizes and binds to Human Caveolin-1 . This antibody is tested and proven to work in the following applications: |
Polyclonal Caveolin-1 Antibody |
|
APG02446G |
Leading Biology |
0.1ml |
EUR 484 |
|
Description: A polyclonal antibody raised in Rabbit that recognizes and binds to Human Caveolin-1 . This antibody is tested and proven to work in the following applications: |
) Anti-Caveolin-1 Rabbit Monoclonal Antibody (RM325) |
|
A1840-50 |
Biovision |
|
EUR 311 |
 Anti-Caveolin-3 Rabbit Monoclonal Antibody |
|
M00990 |
BosterBio |
100ug/vial |
EUR 397 |
|
Description: Rabbit Monoclonal Caveolin-3 Antibody. Validated in WB and tested in Human, Mouse, Rat. |
 Anti-Caveolin-2 Rabbit Monoclonal Antibody |
|
M01574 |
BosterBio |
100ug/vial |
EUR 397 |
|
Description: Rabbit Monoclonal Caveolin-2 Antibody. Validated in IP, IF, IHC, WB and tested in Human. |
 Rabbit Polyclonal Antibody to Human TDP1 |
|
TG2016 |
TopoGen |
250 units |
EUR 414 |
 Anti-Caveolin-1/CAV1 Antibody |
|
PA1514 |
BosterBio |
100ug/vial |
EUR 334 |
Anti-Caveolin-1/CAV1 Antibody |
|
PB9165 |
BosterBio |
100ug/vial |
EUR 334 |
 Anti-Caveolin-1 Rabbit Monoclonal Antibody, Clone#RM325 |
|
M00179-2 |
BosterBio |
100uL |
EUR 385 |
|
Description: Anti-Caveolin-1 Rabbit Monoclonal Antibody, Clone#RM325 tested in WB, IHC, reactive to Human |
 anti-Caveolin 1 |
|
YF-PA10691 |
Abfrontier |
100 ug |
EUR 403 |
|
Description: Rabbit polyclonal to Caveolin 1 |
 polyclonal antibody) Myeloid/lymphoid or mixed-lineage leukemia translocated to 1 (MLLT1) polyclonal antibody |
|
ABP-PAB-10851 |
Allele Biotech |
100 ug |
Ask for price |
|
|
 Caveolin-1 Antibody |
|
33331-100ul |
SAB |
100ul |
EUR 252 |
Caveolin-1 Antibody |
|
33331-50ul |
SAB |
50ul |
EUR 187 |
Caveolin-1 Antibody |
|
48674-100ul |
SAB |
100ul |
EUR 333 |
Caveolin-1 Antibody |
|
48674-50ul |
SAB |
50ul |
EUR 239 |
 Caveolin 1 Antibody |
|
AF5372 |
Affbiotech |
200ul |
EUR 304 |
|
Description: Caveolin 1 Antibody detects endogenous levels of total Caveolin 1. |
Caveolin-1 Antibody |
|
AF6386 |
Affbiotech |
200ul |
EUR 304 |
|
Description: Caveolin-1 Antibody detects endogenous levels of total Caveolin-1. |
Caveolin-1 Antibody |
|
AF0126 |
Affbiotech |
200ul |
EUR 304 |
|
Description: Caveolin-1 antibody detects endogenous levels of total Caveolin-1. |
Caveolin-1 Antibody |
|
A1010-50 |
Biovision |
|
EUR 403 |
 Caveolin 1 antibody |
|
20R-1949 |
Fitzgerald |
50 ug |
EUR 281 |
|
Description: Rabbit polyclonal Caveolin 1 antibody |
Caveolin 1 antibody |
|
20R-2291 |
Fitzgerald |
50 ug |
EUR 281 |
|
Description: Rabbit polyclonal Caveolin 1 antibody |
Caveolin 1 antibody |
|
70R-31113 |
Fitzgerald |
100 ug |
EUR 327 |
|
Description: Rabbit polyclonal Caveolin 1 antibody |
Caveolin 1 antibody |
|
70R-49479 |
Fitzgerald |
100 ul |
EUR 244 |
|
Description: Purified Polyclonal Caveolin 1 antibody |
Caveolin 1 antibody |
|
70R-49480 |
Fitzgerald |
100 ul |
EUR 244 |
|
Description: Purified Polyclonal Caveolin 1 antibody |
Caveolin 1 antibody |
|
70R-35767 |
Fitzgerald |
100 ug |
EUR 327 |
|
Description: Rabbit polyclonal Caveolin 1 antibody |
Caveolin-1 Antibody |
|
8219-002mg |
ProSci |
0.02 mg |
EUR 171.82 |
|
|
|
Description: Caveolin-1 Antibody: Caveolin-1 is a scaffolding protein that is the main component of the caveolae plasma membranes found in most cell types (1). The protein links integrin subunits to the tyrosine kinase FYN, an initiating step in coupling integrins to the Ras-ERK pathway and promoting cell cycle progression (2). The gene is a tumor suppressor gene candidate and a negative regulator of the Ras-p42/44 mitogen-activated kinase cascade (3). Mutations in this gene have been associated with Berardinelli-Seip congenital lipodystrophy (4). |
Caveolin-1 Antibody |
|
8219-01mg |
ProSci |
0.1 mg |
EUR 436.42 |
|
|
|
Description: Caveolin-1 Antibody: Caveolin-1 is a scaffolding protein that is the main component of the caveolae plasma membranes found in most cell types (1). The protein links integrin subunits to the tyrosine kinase FYN, an initiating step in coupling integrins to the Ras-ERK pathway and promoting cell cycle progression (2). The gene is a tumor suppressor gene candidate and a negative regulator of the Ras-p42/44 mitogen-activated kinase cascade (3). Mutations in this gene have been associated with Berardinelli-Seip congenital lipodystrophy (4). |
 Rabbit Polyclonal Antibody to Human Topoisomerase IIb |
|
TG2010-3 |
TopoGen |
250 units |
EUR 414 |
 Rabbit Polyclonal Antibody to Human Topoisomerase IIIb |
|
TG2010-4 |
TopoGen |
250 units |
EUR 380 |
 Anti-Caveolin-3 Antibody |
|
A00990 |
BosterBio |
100ug |
EUR 765 |
|
Description: Rabbit Polyclonal Caveolin-3 Antibody. Validated in IF, WB and tested in Human, Mouse, Rat. |
 antibody) Anti-Phospho-Caveolin-1 (Y14) antibody |
|
STJ90210 |
St John's Laboratory |
200 µl |
EUR 197 |
|
Description: Rabbit polyclonal to Phospho-Caveolin-1 (Y14). |
 Polyclonal Antibody (Human, Mouse)) Caveolin 1 (CAV1) Polyclonal Antibody (Human, Mouse) |
|
4-PAA214Hu01 |
Cloud-Clone |
-
EUR 232.00
-
EUR 2285.00
-
EUR 574.00
-
EUR 289.00
-
EUR 208.00
|
- 100ul
- 10ml
- 1ml
- 200ul
- 20ul
|
|
|
|
Description: A Rabbit polyclonal antibody against Human, Mouse Caveolin 1 (CAV1) |
 Polyclonal Antibody) Caveolin-1 (phospho Tyr14) Polyclonal Antibody |
|
ES1279-50ul |
ELK Biotech |
50ul |
EUR 207 |
|
Description: A Rabbit Polyclonal antibody against Caveolin-1 (phospho Tyr14) from Human/Mouse/Rat. This antibody is tested and validated for WB, ELISA, WB, ELISA |
Caveolin-1 (phospho Tyr14) Polyclonal Antibody |
|
ES1279-100ul |
ELK Biotech |
100ul |
EUR 279 |
|
Description: A Rabbit Polyclonal antibody against Caveolin-1 (phospho Tyr14) from Human/Mouse/Rat. This antibody is tested and validated for WB, ELISA, WB, ELISA |
Caveolin-1 (phospho Tyr14) Polyclonal Antibody |
|
ABP50280-003ml |
Abbkine |
0.03ml |
EUR 158 |
|
|
|
Description: A polyclonal antibody for detection of Caveolin-1 phospho Tyr14) from Human, Mouse, Rat. This Caveolin-1 phospho Tyr14) antibody is for WB, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from human Caveolin-1 around the phosphorylation site of Y14 |
Caveolin-1 (phospho Tyr14) Polyclonal Antibody |
|
ABP50280-01ml |
Abbkine |
0.1ml |
EUR 289 |
|
|
|
Description: A polyclonal antibody for detection of Caveolin-1 phospho Tyr14) from Human, Mouse, Rat. This Caveolin-1 phospho Tyr14) antibody is for WB, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from human Caveolin-1 around the phosphorylation site of Y14 |
Caveolin-1 (phospho Tyr14) Polyclonal Antibody |
|
ABP50280-02ml |
Abbkine |
0.2ml |
EUR 414 |
|
|
|
Description: A polyclonal antibody for detection of Caveolin-1 phospho Tyr14) from Human, Mouse, Rat. This Caveolin-1 phospho Tyr14) antibody is for WB, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from human Caveolin-1 around the phosphorylation site of Y14 |
) Polyclonal CAV1 / Caveolin 1 Antibody (Internal) |
|
APG02439G |
Leading Biology |
0.05mg |
EUR 484 |
|
Description: A polyclonal antibody raised in Goat that recognizes and binds to Human CAV1 / Caveolin 1 (Internal). This antibody is tested and proven to work in the following applications: |
 Polyclonal Antibody (Mouse)) Caveolin 1 (CAV1) Polyclonal Antibody (Mouse) |
|
4-PAA214Mu01 |
Cloud-Clone |
-
EUR 236.00
-
EUR 2338.00
-
EUR 586.00
-
EUR 294.00
-
EUR 209.00
|
- 100ul
- 10ml
- 1ml
- 200ul
- 20ul
|
|
|
|
Description: A Rabbit polyclonal antibody against Mouse Caveolin 1 (CAV1) |
 Anti-Sumo 1 Rabbit Monoclonal Antibody |
|
M00631-1 |
BosterBio |
100ug/vial |
EUR 397 |
|
Description: Rabbit Monoclonal Sumo 1 Antibody. Validated in IP, IF, IHC, WB and tested in Human, Mouse, Rat. |
 Anti-Cytokeratin 1 Rabbit Monoclonal Antibody |
|
M01639-1 |
BosterBio |
100ug/vial |
EUR 397 |
|
Description: Rabbit Monoclonal Cytokeratin 1 Antibody. Validated in WB and tested in Human, Mouse, Rat. |
) Rabbit Polyclonal Antibody to Human Topoisomerase I (Rabbit Serum) |
|
TG2012-2 |
TopoGen |
250 ul |
EUR 380 |
 Caveolin-1 Rabbit mAb |
|
A19006-100ul |
Abclonal |
100 ul |
EUR 410 |
Caveolin-1 Rabbit mAb |
|
A19006-200ul |
Abclonal |
200 ul |
EUR 571 |
Caveolin-1 Rabbit mAb |
|
A19006-20ul |
Abclonal |
20 ul |
EUR 221 |
Caveolin-1 Rabbit mAb |
|
A19006-50ul |
Abclonal |
50 ul |
EUR 287 |
 with goat anti-rabbit HRP secondary antibody) Anti-CETP Antibody (polyclonal rabbit anti-human, mouse, rat) with goat anti-rabbit HRP secondary antibody |
|
EXOAB-CETP-1 |
SBI |
25 ul |
EUR 219 |
 Mouse Monoclonal Antibody to Human Topoisomerase IIα |
|
TG2010-1 |
TopoGen |
50 units |
EUR 369 |
 Polyclonal Antibody (Human, Mouse), APC) Caveolin 1 (CAV1) Polyclonal Antibody (Human, Mouse), APC |
|
4-PAA214Hu01-APC |
Cloud-Clone |
-
EUR 323.00
-
EUR 2969.00
-
EUR 836.00
-
EUR 409.00
-
EUR 210.00
|
- 100ul
- 10ml
- 1ml
- 200ul
- 20ul
|
|
|
|
Description: A Rabbit polyclonal antibody against Human, Mouse Caveolin 1 (CAV1). This antibody is labeled with APC. |
 Polyclonal Antibody (Human, Mouse), Biotinylated) Caveolin 1 (CAV1) Polyclonal Antibody (Human, Mouse), Biotinylated |
|
4-PAA214Hu01-Biotin |
Cloud-Clone |
-
EUR 295.00
-
EUR 2235.00
-
EUR 671.00
-
EUR 358.00
-
EUR 212.00
|
- 100ul
- 10ml
- 1ml
- 200ul
- 20ul
|
|
|
|
Description: A Rabbit polyclonal antibody against Human, Mouse Caveolin 1 (CAV1). This antibody is labeled with Biotin. |
 Polyclonal Antibody (Human, Mouse), Cy3) Caveolin 1 (CAV1) Polyclonal Antibody (Human, Mouse), Cy3 |
|
4-PAA214Hu01-Cy3 |
Cloud-Clone |
-
EUR 390.00
-
EUR 3917.00
-
EUR 1073.00
-
EUR 504.00
-
EUR 239.00
|
- 100ul
- 10ml
- 1ml
- 200ul
- 20ul
|
|
|
|
Description: A Rabbit polyclonal antibody against Human, Mouse Caveolin 1 (CAV1). This antibody is labeled with Cy3. |
 Polyclonal Antibody (Human, Mouse), FITC) Caveolin 1 (CAV1) Polyclonal Antibody (Human, Mouse), FITC |
|
4-PAA214Hu01-FITC |
Cloud-Clone |
-
EUR 279.00
-
EUR 2395.00
-
EUR 688.00
-
EUR 347.00
-
EUR 188.00
|
- 100ul
- 10ml
- 1ml
- 200ul
- 20ul
|
|
|
|
Description: A Rabbit polyclonal antibody against Human, Mouse Caveolin 1 (CAV1). This antibody is labeled with FITC. |
 Polyclonal Antibody (Human, Mouse), HRP) Caveolin 1 (CAV1) Polyclonal Antibody (Human, Mouse), HRP |
|
4-PAA214Hu01-HRP |
Cloud-Clone |
-
EUR 297.00
-
EUR 2589.00
-
EUR 741.00
-
EUR 371.00
-
EUR 199.00
|
- 100ul
- 10ml
- 1ml
- 200ul
- 20ul
|
|
|
|
Description: A Rabbit polyclonal antibody against Human, Mouse Caveolin 1 (CAV1). This antibody is labeled with HRP. |
 Polyclonal Antibody (Human, Mouse), PE) Caveolin 1 (CAV1) Polyclonal Antibody (Human, Mouse), PE |
|
4-PAA214Hu01-PE |
Cloud-Clone |
-
EUR 279.00
-
EUR 2395.00
-
EUR 688.00
-
EUR 347.00
-
EUR 188.00
|
- 100ul
- 10ml
- 1ml
- 200ul
- 20ul
|
|
|
|
Description: A Rabbit polyclonal antibody against Human, Mouse Caveolin 1 (CAV1). This antibody is labeled with PE. |
 Rabbit Anti-Human ATF2 Polyclonal Antibody, aa.serine 60-64 or 42-46 |
|
CPB-944RH |
Creative Diagnostics |
100 ul |
EUR 460 |
 Rabbit Anti-Human ATF2 Polyclonal Antibody, aa.67-71 or 49-53 |
|
CPB-945RH |
Creative Diagnostics |
100 ul |
EUR 460 |
 Rabbit Anti-Human ATF2 Polyclonal Antibody, aa.69-73 or 51-55 |
|
CPB-946RH |
Creative Diagnostics |
100 ul |
EUR 460 |
 Rabbit Anti-Human ATF2 Polyclonal Antibody, aa.71-75 or 53-57 |
|
CPB-947RH |
Creative Diagnostics |
100 ul |
EUR 460 |
 Rabbit Anti-Human ATF2 Polyclonal Antibody, aa.110-114 or 92-96 |
|
CPB-948RH |
Creative Diagnostics |
100 ul |
EUR 460 |
 Antibody) Caveolin 1 (CAV1) Antibody |
|
abx122002-100ug |
Abbexa |
100 ug |
EUR 391 |
|
|
Caveolin 1 (CAV1) Antibody |
|
20-abx125305 |
Abbexa |
-
EUR 495.00
-
EUR 704.00
-
EUR 356.00
|
|
|
|
Caveolin 1 (CAV1) Antibody |
|
20-abx116788 |
Abbexa |
|
|
|
|
 Antibody) Caveolin-1 (CAV1) Antibody |
|
20-abx137365 |
Abbexa |
-
EUR 704.00
-
EUR 328.00
-
EUR 230.00
|
|
|
|
Caveolin 1 (CAV1) Antibody |
|
20-abx100474 |
Abbexa |
-
EUR 398.00
-
EUR 133.00
-
EUR 1107.00
-
EUR 537.00
-
EUR 314.00
|
- 100 ug
- 10 ug
- 1 mg
- 200 ug
- 50 ug
|
|
|
Caveolin 1 (CAV1) Antibody |
|
20-abx100475 |
Abbexa |
-
EUR 411.00
-
EUR 133.00
-
EUR 1135.00
-
EUR 551.00
-
EUR 314.00
|
- 100 ug
- 10 ug
- 1 mg
- 200 ug
- 50 ug
|
|
|
Caveolin 1 (CAV1) Antibody |
|
20-abx100476 |
Abbexa |
-
EUR 425.00
-
EUR 133.00
-
EUR 1177.00
-
EUR 578.00
-
EUR 328.00
|
- 100 ug
- 10 ug
- 1 mg
- 200 ug
- 50 ug
|
|
|
 Antibody) Caveolin 1 (pT14) Antibody |
|
20-abx009682 |
Abbexa |
-
EUR 314.00
-
EUR 467.00
-
EUR 203.00
|
|
|
|
 Antibody) Caveolin 1 (pY14) Antibody |
|
abx010493-100ug |
Abbexa |
100 ug |
EUR 439 |
|
|
Under menthol-flavored e-liquid remedy, MMP9 (matrix metallopeptidase 9), PTGS2 (prostaglandin-endoperoxide synthase 2), MYC (MYC proto-oncogene, bHLH transcription issue), HMOX1 (heme oxygenase 1), NOS3 (nitric oxide synthase 3), and CAV1 (caveolin 1) had been predicted as key genes. In addition, we recognized associated mobile processes, together with inflammatory responses, oxidative stress and carcinogenesis, underneath publicity to tobacco- and menthol-flavored e-liquids. We recognized differentially expressed genes and associated mobile processes and gene signaling pathways after e-cigarette publicity in human center ear cells. These findings could present helpful proof for understanding the impact of e-cigarette publicity.
