Small extracellular vesicles containing miR-192/215 mediate hypoxia-induced cancer-associated fibroblast development in head and neck squamous cell carcinoma

March 9, 2021

The mechanisms underlying the hypoxic most cancers cell-mediated differentiation of cancer-associated fibroblasts (CAFs) haven’t been elucidated but. The current examine confirmed that the hypoxic head and neck squamous cell carcinoma (HNSCC) cells promoted CAF-like differentiation via secreting TGF-β and small extracellular vesicles (sEVs) that include enhanced ranges of miR-192/215 household miRNAs. Caveolin-1 (CAV1), which is a goal gene of miR-192/215, inhibited the TGF-β/SMAD signaling and promoted CAF-like differentiation of the fibroblasts. Restoring the degrees of CAV1 inhibited the hypoxic sEV- and TGF-β-induced CAF-like differentiation.

The enhanced ranges of miR-192/215 encapsulated in the HNSCC tissue-derived sEVs (however not serum-derived sEVs) indicated hypoxic and aggressive most cancers stroma. miR-215 in the tumor tissue-derived sEVs (however not circulating sEVs) was correlated with poor general survival of sufferers with HNSCC. This examine demonstrated that sEVs perform as a “courier” to ship miRNAs from the most cancers cells to the fibroblasts, which promotes the reworking of the hypoxic tumor microenvironment, and that most cancers tissue-derived sEV may doubtlessly function a supply of biomarker.

The intention of this examine was to analyze utilizing myogenic differentiation of adipose stem cells for the remedy of feminine pelvic ground dysfunction (PFD) and aimed to additional examine the influences of microRNA-124-3p (miR-124-3p) in the method of myogenic differentiation of adipose-derived stem cells (ADSCs) via concentrating on Caveolin-1 (Cav1) throughout PFD in Sprague Dawley (SD) rats.

Comprehensive evaluation of lncRNA-associated ceRNA community reveals the novel potential of lncRNA, miRNA and mRNA biomarkers in human rectosigmoid junction most cancers

Although accumulating proof has confirmed the potential organic capabilities of lengthy non-coding RNAs (lncRNAs) as aggressive endogenous RNAs (ceRNAs) in colorectal tumorigenesis and development, few research have targeted on rectosigmoid junction most cancers. In the current examine, a complete evaluation was carried out to discover lncRNA-mediated ceRNA implications and their potential worth for prognosis. lncRNA, microRNA (miR/miRNA) and mRNA expression profiles had been downloaded from The Cancer Genome Atlas database.

Subsequently, a lncRNA-miRNA-mRNA regulatory community was constructed to guage the capabilities of those differentially expressed genes on general survival (OS) for rectosigmoid junction most cancers. As a outcome, a rectosigmoid junction cancer-specific ceRNA community was efficiently constructed with 7 differentially expressed (DE)lncRNAs, 16 DEmiRNAs and 71 DEmRNAs. Among the community, one DElncRNA (small nucleolar RNA host gene 20) and three mRNAs (sodium- and chloride-dependent taurine transporter, fibroblast progress issue 13 and tubulin polyglutamylase TTLL7) had been considerably related to OS (P<0.05).

Additionally, two lncRNAs (KCNQ1OT1 and MIR17HG) interacted with many of the DEmiRNAs. Notably, two top-ranked miRNAs (hsa-miR-374a-5p and hsa-miR-374b-5p) related networks had been recognized to be markedly related to the pathogenesis. Furthermore, 4 DEmRNAs (caveolin-1, MET, filamin-A and AKT3) had been enriched in the Kyoto Encylopedia of Gene and Genomes pathway evaluation, in addition to being included in the ceRNA community. In abstract, the current outcomes revealed {that a} particular lncRNA-miRNA-mRNA community was related to rectosigmoid junction most cancers, offering a number of molecules that could be used as novel prognostic biomarkers and therapeutic targets.

Small extracellular vesicles containing miR-192/215 mediate hypoxia-induced cancer-associated fibroblast development in head and neck squamous cell carcinoma

Endocytic pathway inhibition attenuates extracellular vesicle-induced discount of chemosensitivity to bortezomib in a number of myeloma cells

Extracellular vesicles (EVs), together with exosomes and microvesicles, derived from bone marrow stromal cells (BMSCs) have been demonstrated as key components in the development and drug resistance of a number of myeloma (MM). EV uptake entails a wide range of mechanisms which largely depend upon the vesicle origin and recipient cell kind. The intention of the current examine was to establish the mechanisms concerned in the uptake of BMSC-derived small EVs (sEVs) by MM cells, and to guage the anti-MM impact of concentrating on this course of.

Human BMSC-derived sEVs had been recognized by transmission electron microscopy, nanoparticle monitoring evaluation, and western blot. The results of chemical inhibitors and shRNA-mediated knockdown of endocytosis-associated genes on sEV uptake and cell apoptosis had been analyzed by circulation cytometry. The anti-MM impact of blocking sEV uptake was evaluated in vitro and in a xenograft MM mouse mannequin.

sEVs derived from BMSC had been taken up by MM cells in a time- and dose-dependent method, and subsequently promoted MM cell biking and decreased their chemosensitivity to bortezomib. Chemical endocytosis inhibitors concentrating on heparin sulphate proteoglycans, actin, tyrosine kinase, dynamin-2, sodium/proton exchangers, or phosphoinositide 3-kinases considerably decreased MM cell internalization of BMSC-derived sEVs.

Moreover, shRNA-mediated knockdown of endocytosis-associated proteins, together with caveolin-1, flotillin-1, clathrin heavy chain, and dynamin-2 in MM cells suppressed sEV uptake. Furthermore, an endocytosis inhibitor concentrating on dynamin-2 preferentially suppressed the uptake of sEV by major MM cells ex vivo and enhanced the anti-MM results of bortezomib in vitro and in a mouse mannequin. Clathrin- and caveolin-dependent endocytosis and macropinocytosis are the predominant routes of sEV-mediated communication between BMSCs and MM cells, and inhibiting endocytosis attenuates sEV-induced discount of chemosensitivity to bortezomib, and thus enhances its anti-MM properties.

Caveolin-1
AP81403 1mg
EUR 2640

Caveolin-1
AP81634 1mg
EUR 2640

Caveolin-1
MC-899 4D6 Ask for price

Caveolin-1 Peptide
45-027P 0.1 mg
EUR 405.6
Description: (IN) Caveolin-1 Peptide

Caveolin-1 Peptide
8219P 0.05 mg
EUR 197.7
Description: Caveolin-1 Peptide

Caveolin-1 Antibody
33331-100ul 100ul
EUR 302.4

Caveolin-1 Antibody
33331-50ul 50ul
EUR 224.4

Caveolin-1 Antibody
48674-100ul 100ul
EUR 399.6

Caveolin-1 Antibody
48674-50ul 50ul
EUR 286.8

Caveolin-1 Antibody
E033331 100μg/100μl
EUR 255
Description: Available in various conjugation types.

Caveolin-1 Antibody
E18-6386-1 50μg/50μl
EUR 145
Description: Available in various conjugation types.

Caveolin-1 Antibody
E18-6386-2 100μg/100μl
EUR 225
Description: Available in various conjugation types.

Caveolin-1 Antibody
E18-0126-1 50μg/50μl
EUR 145
Description: Available in various conjugation types.

Caveolin-1 Antibody
E18-0126-2 100μg/100μl
EUR 225
Description: Available in various conjugation types.

Caveolin-1 Antibody
E11-0139C 100μg/100μl
EUR 225
Description: Available in various conjugation types.

Caveolin-1 Antibody
E80407-6 100μl
EUR 225
Description: Available in various conjugation types.

Caveolin-1 Antibody
E8M0407-28 100ul
EUR 225
Description: Available in various conjugation types.

Caveolin-1 Antibody
A1010-50 each
EUR 483.6

Caveolin-1 Antibody
8219-002mg 0.02 mg
EUR 206.18
Description: Caveolin-1 Antibody: Caveolin-1 is a scaffolding protein that is the main component of the caveolae plasma membranes found in most cell types (1). The protein links integrin subunits to the tyrosine kinase FYN, an initiating step in coupling integrins to the Ras-ERK pathway and promoting cell cycle progression (2). The gene is a tumor suppressor gene candidate and a negative regulator of the Ras-p42/44 mitogen-activated kinase cascade (3). Mutations in this gene have been associated with Berardinelli-Seip congenital lipodystrophy (4).

Caveolin-1 Antibody
8219-01mg 0.1 mg
EUR 523.7
Description: Caveolin-1 Antibody: Caveolin-1 is a scaffolding protein that is the main component of the caveolae plasma membranes found in most cell types (1). The protein links integrin subunits to the tyrosine kinase FYN, an initiating step in coupling integrins to the Ras-ERK pathway and promoting cell cycle progression (2). The gene is a tumor suppressor gene candidate and a negative regulator of the Ras-p42/44 mitogen-activated kinase cascade (3). Mutations in this gene have been associated with Berardinelli-Seip congenital lipodystrophy (4).

Caveolin-1 Antibody
8C0139 50ug
EUR 368
Description: Caveolin-1 Antibody

CAVEOLIN-1, Antibody
GWB-A9772C 0.1 mg Ask for price

Caveolin-1 Antibody
RQ4919 100 ug
EUR 356.15
Description: CAV1( Caveolin-1) is a protein that in humans is encoded by the CAV1 gene. The CAV1 gene is mapped to 7q31.2. The scaffolding protein encoded by this gene is the main component of the caveolae plasma membranes found in most cell types. The protein links integrin subunits to the tyrosine kinase FYN, an initiating step in coupling integrins to the Ras-ERK pathway and promoting cell cycle progression. The gene is a tumor suppressor gene candidate and a negative regulator of the Ras-p42/44 MAP kinase cascade. CAV1 and CAV2 are located next to each other on chromosome 7 and express colocalizing proteins that form a stable hetero-oligomeric complex. By using alternative initiation codons in the same reading frame, two isoforms(alpha and beta) are encoded by a single transcript from this gene.

Caveolin-1 Antibody
R30587 100 ug
EUR 356.15
Description: CAV1, Caveolin-1, is a protein that in humans is encoded by the CAV1 gene. The CAV1 gene is mapped to 7q31.2. The scaffolding protein encoded by this gene is the main component of the caveolae plasma membranes found in most cell types. The protein links integrin subunits to the tyrosine kinase FYN, an initiating step in coupling integrins to the Ras-ERK pathway and promoting cell cycle progression. The gene is a tumor suppressor gene candidate and a negative regulator of the Ras-p42/44 MAP kinase cascade. CAV1 and CAV2 are located next to each other on chromosome 7 and express colocalizing proteins that form a stable hetero-oligomeric complex. By using alternative initiation codons in the same reading frame, two isoforms(alpha and beta) are encoded by a single transcript from this gene.

Caveolin-1 Antibody
R31583 100 ug
EUR 356.15
Description: Caveolin-1 is a protein that in humans is encoded by the CAV1 gene. The CAV1 gene is mapped to 7q31.2. The scaffolding protein encoded by this gene is the main component of the caveolae plasma membranes found in most cell types. The protein links integrin subunits to the tyrosine kinase FYN, an initiating step in coupling integrins to the Ras-ERK pathway and promoting cell cycle progression. The gene is a tumor suppressor gene candidate and a negative regulator of the Ras-p42/44 MAP kinase cascade. CAV1 and CAV2 are located next to each other on chromosome 7 and express colocalizing proteins that form a stable hetero-oligomeric complex. By using alternative initiation codons in the same reading frame, two isoforms(alpha and beta) are encoded by a single transcript from this gene.

Dog Caveolin-1 (CAV1)
1-CSB-YP004571DO
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Description: Recombinant Dog Caveolin-1(CAV1) expressed in Yeast

Caveolin 1 antibody
20R-1949 50 ug
EUR 269
Description: Rabbit polyclonal Caveolin 1 antibody

Caveolin 1 antibody
20R-2291 50 ug
EUR 269
Description: Rabbit polyclonal Caveolin 1 antibody

Caveolin 1 Antibody
E18-5372-1 50μg/50μl
EUR 145
Description: Available in various conjugation types.

Caveolin 1 Antibody
E18-5372-2 100μg/100μl
EUR 225
Description: Available in various conjugation types.

Caveolin 1 Antibody
E38PA1160 100ul
EUR 225
Description: Available in various conjugation types.

Caveolin 1 Antibody
E38PA1161 100ul
EUR 225
Description: Available in various conjugation types.

Caveolin 1, Antibody
GWB-2C9A54 7 ml Ask for price

Caveolin 1, Antibody
GWB-2CB3DF 1 ml Ask for price

Caveolin 1 Antibody
AF0126 200ul
EUR 420

Caveolin 1 Antibody
AF5372 200ul
EUR 420

Caveolin 1 Antibody
AF5372-100ul 100ul
EUR 280

Caveolin 1 Antibody
AF5372-200ul 200ul
EUR 350

Caveolin 1 Antibody
AF6386 200ul
EUR 420

Caveolin 1 Antibody
AF6386-100ul 100ul
EUR 280

Caveolin 1 Antibody
AF6386-200ul 200ul
EUR 350

Caveolin 1 antibody
70R-35767 100 ug
EUR 294
Description: Rabbit polyclonal Caveolin 1 antibody

Caveolin 1 antibody
70R-49479 100 ul
EUR 242
Description: Purified Polyclonal Caveolin 1 antibody

Caveolin 1 antibody
70R-49480 100 ul
EUR 242
Description: Purified Polyclonal Caveolin 1 antibody

Caveolin 1 antibody
70R-31113 100 ug
EUR 294
Description: Rabbit polyclonal Caveolin 1 antibody

Caveolin 1 Antibody
ABF5372 100 ug
EUR 525.6

Caveolin- 1 Antibody
ABF6386 100 ug
EUR 525.6

Caveolin- 1 Antibody
ABF0126 100 ug
EUR 525.6

Caveolin 1, Antibody
GWB-DBA3FD 7 ml Ask for price

Caveolin 1 Antibody
GWB-81BDC8 0.1 mg Ask for price

Caveolin 1, Antibody
GWB-95A9FE 1 ml Ask for price

Caveolin 1 Antibody
R33422-100UG 100 ug
EUR 339.15
Description: Additional name(s) for this target protein: CAV1

Caveolin-1 Rabbit pAb
E2340158 100ul
EUR 225
Description: Available in various conjugation types.

Caveolin-1 Rabbit pAb
E2380677 100ul
EUR 225
Description: Available in various conjugation types.

Caveolin-1 Rabbit pAb
E2382762 100ul
EUR 225
Description: Available in various conjugation types.

Caveolin-1 Rabbit mAb
A19006 1000μL
EUR 213.2
Description: A synthetic peptide corresponding to a sequence corresponding to amino acids 25-116 of human CGA(NP_000726.1) and amino acids 21-141 of human LHB(NP_000885.1) .

Caveolin-1 Rabbit mAb
A19006-100ul 100 ul
EUR 492

Caveolin-1 Rabbit mAb
A19006-200ul 200 ul
EUR 685.2

Caveolin-1 Rabbit mAb
A19006-20ul 20 ul
EUR 265.2

Caveolin-1 Rabbit mAb
A19006-50ul 50 ul
EUR 344.4

Caveolin-1 Rabbit mAb
58533 100ul
EUR 339

Caveolin-1 Rabbit mAb
A22417 200μL
EUR 1557.4
Description: Recombinant fusion protein containing a sequence corresponding to amino acids 6-95 of human CRYAA (P02489).

Caveolin-1 (CAV1) Antibody
abx231313-100ug 100 ug
EUR 577.2

Caveolin-1 (CAV1) Antibody
abx231314-100ug 100 ug
EUR 577.2

Caveolin-1 (CAV1) Antibody
20-abx137365
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  • 100 ug
  • 20 ug
  • 5 ug

Caveolin-2
E8ET1607-15 100ul
EUR 275
Description: Available in various conjugation types.

Caveolin-3
E8ET1607-16 100ul
EUR 275
Description: Available in various conjugation types.

Caveolin-2
PC-211 Polyclonal Ask for price

anti- Caveolin-1 antibody
FNab01313 100µg
EUR 606.3
Description: Antibody raised against Caveolin-1

anti- Caveolin-1 antibody
FNab01314 100µg
EUR 606.3
Description: Antibody raised against Caveolin-1

Caveolin 1 Rabbit mAb
E2R22762 100ul
EUR 255
Description: Available in various conjugation types.

Caveolin 1 Rabbit mAb
E2R23746 100ul
EUR 255
Description: Available in various conjugation types.

Caveolin 1 Rabbit mAb
52197 100ul
EUR 499

Caveolin-1 Blocking Peptide
AF0126-BP 1mg
EUR 234

Caveolin-1 Blocking Peptide
AF6386-BP 1mg
EUR 234

Caveolin 1 (CAV1) Antibody
20-abx327354
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  • 100 ug
  • 50 ug

Caveolin 1 (CAV1) Antibody
abx431142-200ul 200 ul
EUR 460.8

Caveolin 1 (CAV1) Antibody
20-abx328161
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  • 100 ug
  • 50 ug

Caveolin 1 (CAV1) Antibody
abx330500-100ul 100 ul
EUR 510

Caveolin 1 (CAV1) Antibody
abx332130-100ul 100 ul
EUR 510

Caveolin 1 (CAV1) Antibody
20-abx100474
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  • 100 ug
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  • 1 mg
  • 200 ug
  • 50 ug

Caveolin 1 (CAV1) Antibody
20-abx100475
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  • 100 ug
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  • 1 mg
  • 200 ug
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Caveolin 1 (CAV1) Antibody
20-abx100476
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  • 100 ug
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  • 1 mg
  • 200 ug
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Caveolin 1 (CAV1) Antibody
20-abx175748
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  • 1 mg
  • 200 ug

Caveolin 1 (CAV1) Antibody
20-abx175750
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  • 100 ug
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  • 1 mg
  • 200 ug
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Caveolin 1 (CAV1) Antibody
20-abx175751
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  • 1 mg
  • 200 ug

Caveolin 1 (CAV1) Antibody
20-abx175752
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  • 1 mg
  • 200 ug

Caveolin 1 (CAV1) Antibody
20-abx175753
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  • Ask for price
  • 1 mg
  • 200 ug

Caveolin 1 (CAV1) Antibody
20-abx175754
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  • 1 mg
  • 200 ug

Caveolin 1 (CAV1) Antibody
20-abx175755
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  • 1 mg
  • 200 ug

Caveolin 1 (CAV1) Antibody
20-abx175756
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  • 1 mg
  • 200 ug

Caveolin 1 (CAV1) Antibody
20-abx171646
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  • 1 mg
  • 200 ug

Caveolin 1 (CAV1) Antibody
20-abx171647
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  • 1 mg
  • 200 ug

Caveolin 1 (CAV1) Antibody
20-abx171648
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  • 1 mg
  • 200 ug

Caveolin 1 (CAV1) Antibody
20-abx171649
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  • 1 mg
  • 200 ug

Caveolin 1 (CAV1) Antibody
20-abx125305
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  • 100 ul
  • 200 ul
  • 50 ul

Caveolin 1 (CAV1) Antibody
20-abx241052
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  • 100 ul
  • 50 ul

Caveolin 1 (CAV1) Antibody
20-abx242330
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  • 100 ul
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Caveolin 1 (CAV1) Antibody
abx122002-100ug 100 ug
EUR 469.2

Caveolin 1 (CAV1) Antibody
20-abx116788
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  • 150 ul
  • 50 ul

Caveolin 1 (CAV1) Antibody
20-abx009491
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  • 100 ul
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Caveolin 1 (CAV1) Antibody
20-abx009492
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  • 100 ul
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Caveolin 1 (CAV1) Antibody
20-abx013031
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  • 100 ug
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Caveolin 1 (CAV1) Antibody
20-abx000539
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  • 100 ul
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Caveolin 1 (CAV1) Antibody
abx019037-100ug 100 ug
EUR 410.4

Caveolin 1 Protein (OVA)
20-abx165517
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  • 100 ug
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  • 1 mg
  • 200 ug
  • 50 ug

Rat Caveolin-1 ELISA kit
E02C0700-192T 192 tests
EUR 1524
Description: A Sandwich ELISA for quantitative measurement of Rat Caveolin-1 in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Rat Caveolin-1 ELISA kit
E02C0700-48 1 plate of 48 wells
EUR 624
Description: A Sandwich ELISA for quantitative measurement of Rat Caveolin-1 in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Rat Caveolin-1 ELISA kit
E02C0700-96 1 plate of 96 wells
EUR 822
Description: A Sandwich ELISA for quantitative measurement of Rat Caveolin-1 in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Dog Caveolin-1 ELISA kit
E08C0700-192T 192 tests
EUR 1524
Description: A Sandwich ELISA for quantitative measurement of Canine Caveolin-1 in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Dog Caveolin-1 ELISA kit
E08C0700-48 1 plate of 48 wells
EUR 624
Description: A Sandwich ELISA for quantitative measurement of Canine Caveolin-1 in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Dog Caveolin-1 ELISA kit
E08C0700-96 1 plate of 96 wells
EUR 822
Description: A Sandwich ELISA for quantitative measurement of Canine Caveolin-1 in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Pig Caveolin-1 ELISA kit
E07C0700-192T 192 tests
EUR 1524
Description: A Sandwich ELISA for quantitative measurement of Porcine Caveolin-1 in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Pig Caveolin-1 ELISA kit
E07C0700-48 1 plate of 48 wells
EUR 624
Description: A Sandwich ELISA for quantitative measurement of Porcine Caveolin-1 in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Pig Caveolin-1 ELISA kit
E07C0700-96 1 plate of 96 wells
EUR 822
Description: A Sandwich ELISA for quantitative measurement of Porcine Caveolin-1 in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Rat Caveolin-1 ELISA Kit
EK1495 96 tests
EUR 599

Recombinant human Caveolin-1
P1754 100ug Ask for price
Description: Recombinant protein for human Caveolin-1

Goat Caveolin-1 ELISA kit
E06C0700-192T 192 tests
EUR 1524
Description: A Sandwich ELISA for quantitative measurement of Goat Caveolin-1 in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Goat Caveolin-1 ELISA kit
E06C0700-48 1 plate of 48 wells
EUR 624
Description: A Sandwich ELISA for quantitative measurement of Goat Caveolin-1 in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Goat Caveolin-1 ELISA kit
E06C0700-96 1 plate of 96 wells
EUR 822
Description: A Sandwich ELISA for quantitative measurement of Goat Caveolin-1 in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Caveolin-1 Cell ELISA Kit
abx595098-96tests 96 tests
EUR 764.4

Rabbit Polyclonal antibody to Caveolin 2 (caveolin 2)
TA308863 100 µl Ask for price

Caveolin 1 (pY14) Antibody
E38PA3159 100ul
EUR 225
Description: Available in various conjugation types.

Caveolin 1 (pT14) Antibody
20-abx009682
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  • 100 ul
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Caveolin 1 (pY14) Antibody
abx010493-100ug 100 ug
EUR 526.8

Human Caveolin-1 ELISA kit
E01C0700-192T 192 tests
EUR 1524
Description: A Sandwich ELISA for quantitative measurement of Human Caveolin-1 in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Human Caveolin-1 ELISA kit
E01C0700-48 1 plate of 48 wells
EUR 624
Description: A Sandwich ELISA for quantitative measurement of Human Caveolin-1 in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Human Caveolin-1 ELISA kit
E01C0700-96 1 plate of 96 wells
EUR 822
Description: A Sandwich ELISA for quantitative measurement of Human Caveolin-1 in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Mouse Caveolin-1 ELISA kit
E03C0700-192T 192 tests
EUR 1524
Description: A Sandwich ELISA for quantitative measurement of Mouse Caveolin-1 in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Mouse Caveolin-1 ELISA kit
E03C0700-48 1 plate of 48 wells
EUR 624
Description: A Sandwich ELISA for quantitative measurement of Mouse Caveolin-1 in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Mouse Caveolin-1 ELISA kit
E03C0700-96 1 plate of 96 wells
EUR 822
Description: A Sandwich ELISA for quantitative measurement of Mouse Caveolin-1 in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Caveolin-1 Polyclonal Antibody
40684-100ul 100ul
EUR 302.4

Caveolin-1 Polyclonal Antibody
40684-50ul 50ul
EUR 224.4

Caveolin-1 Polyclonal Antibody
E040684 100μg/100μl
EUR 255
Description: Available in various conjugation types.

Caveolin-1 Polyclonal Antibody
E20-70685 100ug
EUR 225
Description: Available in various conjugation types.

Caveolin-1 Polyclonal Antibody
E20-70686 100ug
EUR 225
Description: Available in various conjugation types.

Polyclonal Caveolin-1 Antibody
APG02445G 0.05ml
EUR 633.6
Description: A polyclonal antibody raised in Rabbit that recognizes and binds to Human Caveolin-1 . This antibody is tested and proven to work in the following applications:

Polyclonal Caveolin-1 Antibody
APG02446G 0.1ml
EUR 580.8
Description: A polyclonal antibody raised in Rabbit that recognizes and binds to Human Caveolin-1 . This antibody is tested and proven to work in the following applications:

Caveolin-1 Conjugated Antibody
C48674 100ul
EUR 476.4

Caveolin-1 Polyclonal Antibody
ABP50873-003ml 0.03ml
EUR 189.6
Description: A polyclonal antibody for detection of Caveolin-1 from Human, Mouse, Rat. This Caveolin-1 antibody is for WB, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from human Caveolin-1 around the non-phosphorylation site of Y14

Moreover, genetic deletion of caveolin-1 or pharmacological blockade of Tie2 signaling successfully normalizes microvascular construction and barrier perform with attenuated EC-pericyte disassociation and CCM lesion formation in Pdcd10BECKO mice. Our examine establishes a persistent CCM mannequin and uncovers a mechanism by which CCM3 mutation-induced caveolae-Tie2 signaling contributes to CCM pathogenesis.