Human ether-a-go-go-related gene 1 channels are physically linked to beta1 integrins and modulate adhesion-dependent signaling

Adhesive receptors of the integrin household are primarily concerned in cell-extracellular matrix adhesion. Additionally, integrins set off a number of signaling pathways…

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The biology of caveolae: lessons from caveolin knockout mice and implications for human disease

Caveolae, plasma membrane invaginations that function membrane organizing facilities, are present in most cell sorts, however are enriched in adipocytes,…

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Fatal cardiac arrhythmia and long-QT syndrome in a new form of congenital generalized lipodystrophy with muscle rippling (CGL4) due to PTRF-CAVIN mutations

We investigated eight households with a novel subtype of congenital generalized lipodystrophy (CGL4) of whom 5 members had died from sudden cardiac demise…

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Caveolin-2-deficient mice show evidence of severe pulmonary dysfunction without disruption of caveolae

Caveolin-2 is a member of the caveolingenefamily with no identified perform. Although caveolin-2 is coexpressed and heterooligomerizes with caveolin-1 in lots of cell varieties…

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The caveolin proteins

The caveolingenefamily has three members in vertebrates: caveolin-1, caveolin-2, and caveolin-3. So far, most caveolin-related analysis has been carried out in mammals, however the proteins have…

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Expression of caveolin-3 in skeletal, cardiac, and smooth muscle cells. Caveolin-3 is a component of the sarcolemma and co-fractionates with dystrophin and dystrophin-associated glycoproteins

Caveolae are microdomains of the plasma membrane which have been implicated in sign transduction. Caveolin, a 21-24-kDa integral membrane protein, is…

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